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High-Precision Metabolomics

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Biomarkers

Bevital´s panels currently includes 145 biomarkers, which are group by function below. Please note that biomarkers can have multiple functions and be listed in more than one category. Click on the biomarker for detailed informations and literature. 

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Vitamins & Lifestyle

B vitamins

14 markers by LC-MS/MS and microbiological assay

Folate & cobalamin

8 markers by GC- and LC-MS/MS and microbiological assay

Fat soluble vitamins

4 markers by LC-MS/MS

Meat & fish intake

4 markers by GC- and LC-MS/MS

Tobacco & coffee

3 markers by LC-MS/MS

Metabolites & Pathways

AGEs

2 markers by GC-MS/MS

Amino acids and metabolites

31 markers by GC- and LC-MS/MS

Acylcarnitines

23 markers by LC-MS/MS

Choline oxidation pathway

7 markers by GC- and LC-MS/MS

Citric acid cycle

8 markers by GC-MS/MS

Microbiota derived

17 markers by GC-and LC-MS/MS

One carbon metabolism

16 markers by GC- and LC-MS/MS

Transsulfuration

2 markers by GC-MS/MS

Tryptophan metabolites

20 markers by LC-MS/MS

Urea cycle

4 markers by GC- and LC-MS/MS

Others

2 markers by LC-MS/MS

Pathologies

Diabetes

8 markers by GC-, LC-MS/MS and MALDI-TOF MS

Endothelial function

4 markers by LC-MS/MS

Inflammation

6 markers by LC-MS/MS and MALDI-TOF MS (incl. 25 proteoforms)

Ketone bodies

2 markers by GC-MS/MS

Liver pathology

1 markers by GC-MS/MS

Neuroactive

4 markers by LC-MS/MS

Oncometabolites

4 markers by GC-MS/MS

Renal function

3 markers by LC-MS/MS and MALDI-TOF MS (incl. 5 proteoforms)

Uremic toxin

2 markers by GC- and LC-MS/MS

May 15, 2024
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Cardiometabolic
Inflammation
Microbiome
Nutrition
Categories

Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs



Kynurenines, ratio-derived metabolites, proteins





SCFAs, indoles, choline metabolites, amino acid derived





B-vitamins, functional markers, and methyl donors, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
Biomarkers (n)
65
18
20
41
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Amino acids: Alanine, Arginine, Asparagine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Histidine, Isoleucine, Kynurenine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Threonine, Total cysteine, Tryptophan, Tyrosine, Valine

Amino acid catabolites: 2-Aminoadipic acid, 2-Hydroxybutyrate, 3-Hydroxysiobutyrate, α-Hydroxyglutaric acid, β-Alanine, β-Aminoisobutyrate, β-Hydroxy B-methylbutyric acid, Phenylacetylglutamine

Acylcarnities: BB, C0, C2, C3, C3-DC, C4, C4-OH, C4-DC, iC5, C5-DC, C5:1, C6, C8, C10, C12, C14, C14-OH, C16, C16-OH, C18, C18-OH, C18:1, C18:2

TCA metabolites: α-Ketoglutarate, Citrate, Fumarate, Isocitrate, Lactate, Malate, Pyruvate

Ketone bodies: Acetoacetate, 3-Hydroxybutyrate

AGEs: Carboxyethyllysine, Carboxymethyllysine

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Kynurenines: 3-hydroxykynurenine, 3-hydroxyanthranilic acid, Anthranilic acid, Kynurenine, Kynurenic acid, Nicotinic acid, Nicotinamide, N1-methylnicotinamide, Picolinic acid, Quinaldic acid, Quinolinic acid, Xanthurenic acid

Neopterin

Proteins: C-Reactive protein, Calprotectin, Serum Amyloid A

Ratio-derived: Kynurenine/tryptophan ratio, PAr index (PLP, PL, PA)

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SCFAs: Acetate, Butyrate, Formate, Isobutyrate, Isovalerate, Propionate, Valerate, α-Methylbutyrate

Indoles: 3-Indoxyl sulfate, Imidazole propionate, Indole-3-acetamide, Indole-3-acetate, Indole-3-aldehyde, Indole-3-lactate, Indole-3-propionate

Choline metabolites: Choline, Betaine, DMG, TMAO

Amino acid derived: Phenylacetylglutamine

View

B-vitamins, functional markers, and methyl donors: 4-Pyridoxic acid, Betaine, Choline, Cobalamin, Flavin mononucleotide, Folate, Methylmalonic acid, N1-methylnicotinamide, Nicotinamide, Nicotinic acid, Pyridoxal, Pyridoxal 5-phosphate, Pyridoxine, Riboflavin, Thiamine, Thiamine monophosphate, Total homocysteine

Fat-soluble vitamins: 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, α-Tocopherol (Vit. E), All-trans retinol (Vit. A), Phylloquinone (Vit. K1), y-Tocopherol (Vit. E)

Essential amino acids: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

Meat and fish intake: 1-Methylhistidine, 3-Methylhistidine, B-Alanine, Creatine, Creatinine, TMAO

Tobacco use and coffee intake: Cotinine, Trans-3-hydroxycotinine, Trigonelline

Volume (μl)
200
150
250
300
Analytical techniques
GC- and LC-MS/MS
LC- and MALDI-MS
GC- and LC-MS/MS
GC- and LC-MS/MS
Turnaround time (weeks)
1
1
1
1
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