4 reasons to choose BEVITAL

Academic support

Scientists at BEVITAL have for decades been involved in scientific projects and can provide academic support including collaboration and contributions to writing of funding applications and scientific articles. Formally, BEVITAL is an SME that have been approved as a partner in projects funded by the EU Commission, Norwegian Research Council, Norwegian Cancer Society, National Cancer Institute (US), National Institutes of Health (US), and several other funding.

Experience and track records​

BEVITAL was founded in 2003 by members of a research group with more than 25 years experience in bioanalytical technology, including mass spectrometry. The research group / BEVITAL have been partners in several international projects, including EU funded projects, that involve instrument development, establishment of new technologies, and their application in large epidemiological projects. Recently, BEVITAL has participated in a large multicenter lung cancer study, organized within the frame of the lung cancer consortium (LC3), funded by the National Cancer Institute (US), and including 11000 cases and controls recruited from 20 centers, in Europe, US, Asia, and Australia.
BEVITAL´s analytical repertoire includes methods that have been developed by our scientists and technicians. Most methods have been published in leading scientific journals within the fields of analytical technology, including Clinical Chemistry and Analytical Chemistry. Hence, articles reporting on your project results will include reference(s) to articles in prestigious journals.

Precise and quantitative biomarker profiling

The analytical repertoire of BEVITAL covers defined, cross-talking pathways, cofactors involved, and biomarkers reflecting key lifestyle factors (smoking, meat intake, coffee consumption), nutritional status, kidney and endothelial function and inflammation. Biomarkers are allocated to complementary platforms characterized by multiplexing, high capacity (several thousands samples), large dynamic range (from 1 nM to several mM), and low volume consumption to save precious biobank material. More than 120 biomarkers are measured in less than 500 µL.

Notably, all methods based on mass spectrometry include isotope-labelled internal standards. However, not all laboratories/assays include an authentic isotope-labelled internal standards for each analyte. At Bevital we recognize the importance of this, and in order to achieve the best results (Khamis et al, Ulvik et al), we have included an authentic isotope labelled internal standard for each of our biomarkers that are analysed by GC- or LC-MS/MS. In contrast, untargeted metabolomics capture only abundant metabolites and have the inherent weakness of low capacity, low precision, possible assay interference and misidentification. The high assay precision achieved by Bevital (green bars) by use of authentic isotope-labelled internal standards (as compared to using non-authentic internal standards, grey bars) is shown below for a selection of analytes quantified on our GC-MS/MS platform.

Ulvik et al. Anal. Chem. 2021, 93, 76167624: Quantifying precision loss in targeted metabolomics based on mass spectrometry and nonmatching internal standards

Low prices due to low costs

Prices of analyses undertaken by BEVITAL are extremely competitive and are kept at production costs. BEVITAL is owned as a whole by a non-profit foundation, supporting research into vitamin deficiency and related topics. There are no private shareholders and therefore no incentive to inflate the cost and thereby the prices. Futhermore, all instrument maintenance and repair are performed by the technical staff of BEVITAL.

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Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs

Kynurenines, ratio-derived metabolites, proteins

SCFAs, indoles, choline metabolites, amino acid derived

B-vitamins, functional markers, and methyl donors, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
Biomarkers (n)

Amino acids: Alanine, Arginine, Asparagine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Histidine, Isoleucine, Kynurenine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Threonine, Total cysteine, Tryptophan, Tyrosine, Valine

Amino acid catabolites: 2-Aminoadipic acid, 2-Hydroxybutyrate, 3-Hydroxysiobutyrate, α-Hydroxyglutaric acid, β-Alanine, β-Aminoisobutyrate, β-Hydroxy B-methylbutyric acid, Phenylacetylglutamine

Acylcarnities: BB, C0, C2, C3, C3-DC, C4, C4-OH, C4-DC, iC5, C5-DC, C5:1, C6, C8, C10, C12, C14, C14-OH, C16, C16-OH, C18, C18-OH, C18:1, C18:2

TCA metabolites: α-Ketoglutarate, Citrate, Fumarate, Isocitrate, Lactate, Malate, Pyruvate

Ketone bodies: Acetoacetate, 3-Hydroxybutyrate

AGEs: Carboxyethyllysine, Carboxymethyllysine


Kynurenines: 3-hydroxykynurenine, 3-hydroxyanthranilic acid, Anthranilic acid, Kynurenine, Kynurenic acid, Nicotinic acid, Nicotinamide, N1-methylnicotinamide, Picolinic acid, Quinaldic acid, Quinolinic acid, Xanthurenic acid


Proteins: C-Reactive protein, Calprotectin, Serum Amyloid A

Ratio-derived: Kynurenine/tryptophan ratio, PAr index (PLP, PL, PA)


SCFAs: Acetate, Butyrate, Formate, Isobutyrate, Isovalerate, Propionate, Valerate, α-Methylbutyrate

Indoles: 3-Indoxyl sulfate, Imidazole propionate, Indole-3-acetamide, Indole-3-acetate, Indole-3-aldehyde, Indole-3-lactate, Indole-3-propionate

Choline metabolites: Choline, Betaine, DMG, TMAO

Amino acid derived: Phenylacetylglutamine


B-vitamins, functional markers, and methyl donors: 4-Pyridoxic acid, Betaine, Choline, Cobalamin, Flavin mononucleotide, Folate, Methylmalonic acid, N1-methylnicotinamide, Nicotinamide, Nicotinic acid, Pyridoxal, Pyridoxal 5-phosphate, Pyridoxine, Riboflavin, Thiamine, Thiamine monophosphate, Total homocysteine

Fat-soluble vitamins: 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, α-Tocopherol (Vit. E), All-trans retinol (Vit. A), Phylloquinone (Vit. K1), y-Tocopherol (Vit. E)

Essential amino acids: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

Meat and fish intake: 1-Methylhistidine, 3-Methylhistidine, B-Alanine, Creatine, Creatinine, TMAO

Tobacco use and coffee intake: Cotinine, Trans-3-hydroxycotinine, Trigonelline

Volume (μl)
Analytical techniques
GC- and LC-MS/MS
GC- and LC-MS/MS
GC- and LC-MS/MS
Turnaround time (weeks)

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