BEVITAL AS

Assessment of Disease Risk by Targeted Metabolomics

Assessment of Disease Risk
by Targeted Metabolomics
Updated 10 hours ago
Updated 10 hours ago

Download list of biomarkers here

Vitamins & Lifestyle

B vitamins, folate and cobalamin, fat soluble vitamins, tobacco and coffee, meat and fish intake.

Pathologies & Physiology

Diabetes, endothelial function, inflammation, keton bodies, liver pathology, neuroactive, oncometabolites, renal function, uremic toxin.

Metabolites & Pathways

AGEs, amino acids and metabolites, acylcarnitines, choline oxidation pathway, citric acid cycle, microbiota derived, one carbon metabolism, transsulfuration, tryptophan metabolites, urea cycle, others.

Platforms are organized according the letters A – I

GC-MS/MS

A: Short-chain fatty acids.
B: Amino and carboxylic acids. TCA metabolites and intermediates.

LC-MS/MS

C: Choline derivatives. Charged, methylated or sulfur amino acids.
     Short-chain acylcarnitines.
D: Kynurenine pathway and B vitamins.
E: Folate species and catabolites.
H: Lipid-soluble vitamins and long-chain acylcarnitines.
I: Short-, medium-, and long-chain acylcarnitines (under development).

MALDI-TOF MS

G: Protein biomarkers (C-reactive protein, serum amyloid A, calprotectin, cystatin C) and their proteoforms. HbA1c.

Microbiological assay

F: Folate and cobalamin.

Our Services

Platform selection

Choice of biomarker panels and analytical platforms can be crucial for the project outcome. Our experts will help you by a pre-analytical evaluation to maximise data quality and quantity at minimal sample consumption.

Data report

Customers receive a detailed report including metabolite concentrations, LODs, missing data diagnosis, quality controls, CVs, and basic data plots.

Data analysis

We offer academic support by our scientists using sophisticated statistical methods based on R and Shiny apps.

Literature

Our website provides detailed information about all offered biomarkers, metabolites and pathways, and pre-analytical stability including pdfs of scientific articles.

High precision data including low abundance biomarkers by targeted metabolomics and use of authentic isotope-labelled internal standards

Disease related biomarkers and comprehensive coverage of whole pathways

More than 25 years of experience in chromatography and mass spectrometry

Scientific support from analysis planning to data interpretation

Track record in international, EU-, and NIH-funded projects

Competitive pricing due to low costs

Systemic Activation of the Kynurenine Pathway in Graves` Disease with and without Ophthalmopathy
Hans Olav Ueland et al., J Clin Endocrinol Metab. 2023 Jan 6 Online ahead of print.
PDF
Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival - the FOCUS Consortium
Biljana Gigic et al., BMJ Open. 2022 Dec 22;12(12)
PDF
Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
Daniëlle D B Holthuijsen et al., Nutrients. 2022 Dec 3;14(23):5151.
PDF
Inflammation, sex, blood pressure changes and hypertension in midlife: the Hordaland Health Study
Ester Kringeland et al., J Hum Hypertens. 2022 Nov 18. Online ahead of print.
PDF
A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status
Michelle Clements et al., J Bone Miner Res. 2022 Sep 21. Online ahead of print.
PDF
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The Influence of Preanalytical Biospecimen Handling on the Measurement of B Vitamers, Amino Acids, and Other Metabolites in Blood
Kara A Michels et al., Biopreserv Biobank. 2023 Jan 9. Online ahead of print.
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients
Leiv Otto Watne et al., J Clin Invest. 2023 Jan 17;133(2)
PDF
Assessment of vitamin B6 status in never-pregnant, pregnant and postpartum women and their infants
Anne-Lise Bjørke-Monsen et al., Eur J Nutr. 2022 Nov 1. Online ahead of print.
PDF
Stable isotope ratios of nitrogen and carbon as biomarkers of a vegan diet
Jutta Dierkes et al., Eur J Nutr. 2022 Sep 10. Online ahead of print.
PDF
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Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity
Ingrid V Hagen et al., BMC Nutr. 2023 Jan 11;9(1):10.
PDF
Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT-A Systematic Review
Tore I M Aarsland et al., Pharmaceuticals. 2022 Nov 19;15(11),1439.
PDF
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Stein-Erik H Solvang et al., Oxid Med Cell Longev. 2022 Oct 21. eCollection 2022.
PDF
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Joanna L Clasen et al., Int J Cancer. 2022 Sep 1;151(5):708-716. Epub 2022 Apr 16.
PDF
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20 %

Median CV on
GC-MS/MS

20 %

Median CV on
LC-MS/MS

0

Publications since 2007

> 0

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