High-Precision Metabolomics

High-Precision Metabolomics

Updated 3 months ago
Updated 3 months ago

Vitamins & Lifestyle

B vitamins, folate and cobalamin, fat soluble vitamins, tobacco and coffee, meat and fish intake.

Metabolites & Pathways

AGEs, amino acids and metabolites, acylcarnitines, choline oxidation pathway, citric acid cycle, microbiota derived, one carbon metabolism, transsulfuration, tryptophan metabolites, urea cycle, others.

Pathologies & Physiology

Diabetes, endothelial function, inflammation, keton bodies, liver pathology, neuroactive, oncometabolites, renal function, uremic toxin.

Olink Proteomics Panels

Cardiometabolic, cardiovascular, cell regulation, cytokine, development, imunne response, immuno-oncology, inflammation, metabolism, mouse exploratory, neurology, neuro exploratory, oncology, organ damage.


A: Short-chain fatty acids.
B: Amino and carboxylic acids. TCA metabolites and intermediates.


C: Choline derivatives. Charged, methylated or sulfur amino acids.
D: Kynurenine pathway and B vitamins.
E: Folate species and catabolites.
H: Lipid-soluble vitamins.
I:  Short-, medium-, and long-chain acylcarnitines.


G: Protein biomarkers (C-reactive protein, serum amyloid A, calprotectin, cystatin C) and their proteoforms. HbA1c.

Microbiological assay

F: Folate and cobalamin.


BEVITAL is a service provider of Olink and offers Olink® Target 96&48 and Flex panels for high-quality proteomics.
Watch our 2023 seminar video to learn more about these platforms.


BEVITAL is a service provider of Olink and offers Olink® Target 96&48 and Flex panels for high-quality proteomics.
Watch our 2023 seminar video to learn more about these platforms.


Panel selection

Choice of biomarker panels and analytical platforms are crucial for the project outcome. A pre-analytical evaluation by our experts will help you to select or design an optimal biomarker panel, to maximise data quality and quantity at minimal sample consumption and costs.

Sample analysis and data report

Customers receive a detailed analysis report including metabolite concentrations, LODs, missing data diagnosis, quality controls, CVs, and basic data plots.

Data analysis and publication

Our scientists can support your data analysis by sophisticated statistical methods based on R and Shiny apps. If requested, BEVITAL can provide academic support to writing of funding application and scientific articles.


Our website provides detailed information about the offered biomarkers, metabolites and pathways, and pre-analytical stability including pdfs of scientific articles. Bevital´s scientists have published or co-authored more than 500 publications in the last 2 decades.

Higher concentrations of kynurenic acid in CSF are associated with the slower clinical progression of Alzheimer's disease
Anne-Brita Knapskog et al., Alzheimers Dement. 2023 Jun 2. Online ahead of print.
B-vitamin Treatment Modifies the Mortality Risk Associated with Calcium Channel Blockers in Patients with Suspected Stable Angina Pectoris: A Prospective Cohort Study
Indu Dhar et al., Am J Clin Nutr. 2023 Apr 28. Online ahead of print.
The serum kynurenine pathway metabolic profile is associated with overweight and obesity in multiple sclerosis
Marie Kupjetz et al., Mult Scler Relat Disord. 2023 Mar 1;72:104592. Online ahead of print.
Cystatin C proteoforms in chronic kidney disease
Helene Dahl et al., PLoS One. 2023 Feb 1;18(2):e0269436.
Systemic Activation of the Kynurenine Pathway in Graves` Disease with and without Ophthalmopathy
Hans Olav Ueland et al., J Clin Endocrinol Metab. 2023 Jan 6 Online ahead of print.
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Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
Mona Synnøve Bjune et al., EBioMedicine. 2023 May
Impaired adipocyte SLC7A10 promotes lipid storage in association with insulin resistance and altered BCAA metabolism
Regine Å Jersin et al., J Clin Endocrinol Metab. 2023 Mar 14. Online ahead of print.
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium
Øvind Midttun et al., Sci Rep. 2023 Jan 18;13(1):1011.
The Influence of Preanalytical Biospecimen Handling on the Measurement of B Vitamers, Amino Acids, and Other Metabolites in Blood
Kara A Michels et al., Biopreserv Biobank. 2023 Jan 9. Online ahead of print.
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients
Leiv Otto Watne et al., J Clin Invest. 2023 Jan 17;133(2)
Stable isotope ratios of nitrogen and carbon as biomarkers of a vegan diet
Jutta Dierkes et al., Eur J Nutr. 2023; 62(1): 433–441.
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A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
Giulietta S Monasso et al., Epigenetics. 2023; 18(1)
Healthy Nordic diet and associations with plasma concentrations of metabolites in the choline oxidation pathway: a cross-sectional study from Northern Sweden
André Hesselink et al., Nutr J. 2023 May 17;22(1):26
The effect of vitamin B12 supplementation during pregnancy on infant growth and development in Nepal: a community-based, double-blind, randomised, placebo-controlled trial
Ram K Chandyo et al., Lancet. 2023 May 6;401(10387):1508-1517.
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Indu Dhar et al., J Intern Med. 2023 Jan 22. Online ahead of print.
Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity
Ingrid V Hagen et al., BMC Nutr. 2023 Jan 11;9(1):10.
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Personalized customer service from biomarker selection to data interpretation and publication.

Disease related biomarkers and comprehensive coverage of whole pathways.

High-precision data including low abundance biomarkers by targeted metabolomics and use of authentic isotope-labelled internal standards.

Combined metabolomic and proteomic analyses for cross-validation and integrated omics.

Track record in international, EU-, and NIH-funded projects.

Interested in our services?

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Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs

Kynurenines, ratio-derived metabolites, proteins

SCFAs, indoles, choline metabolites, amino acid derived

B-vitamins, functional markers, and methyl donors, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
Biomarkers (n)

Amino acids: Alanine, Arginine, Asparagine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Histidine, Isoleucine, Kynurenine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Threonine, Total cysteine, Tryptophan, Tyrosine, Valine

Amino acid catabolites: 2-Aminoadipic acid, 2-Hydroxybutyrate, 3-Hydroxysiobutyrate, α-Hydroxyglutaric acid, β-Alanine, β-Aminoisobutyrate, β-Hydroxy B-methylbutyric acid, Phenylacetylglutamine

Acylcarnities: BB, C0, C2, C3, C3-DC, C4, C4-OH, C4-DC, iC5, C5-DC, C5:1, C6, C8, C10, C12, C14, C14-OH, C16, C16-OH, C18, C18-OH, C18:1, C18:2

TCA metabolites: α-Ketoglutarate, Citrate, Fumarate, Isocitrate, Lactate, Malate, Pyruvate

Ketone bodies: Acetoacetate, 3-Hydroxybutyrate

AGEs: Carboxyethyllysine, Carboxymethyllysine


Kynurenines: 3-hydroxykynurenine, 3-hydroxyanthranilic acid, Anthranilic acid, Kynurenine, Kynurenic acid, Nicotinic acid, Nicotinamide, N1-methylnicotinamide, Picolinic acid, Quinaldic acid, Quinolinic acid, Xanthurenic acid


Proteins: C-Reactive protein, Calprotectin, Serum Amyloid A

Ratio-derived: Kynurenine/tryptophan ratio, PAr index (PLP, PL, PA)


SCFAs: Acetate, Butyrate, Formate, Isobutyrate, Isovalerate, Propionate, Valerate, α-Methylbutyrate

Indoles: 3-Indoxyl sulfate, Imidazole propionate, Indole-3-acetamide, Indole-3-acetate, Indole-3-aldehyde, Indole-3-lactate, Indole-3-propionate

Choline metabolites: Choline, Betaine, DMG, TMAO

Amino acid derived: Phenylacetylglutamine


B-vitamins, functional markers, and methyl donors: 4-Pyridoxic acid, Betaine, Choline, Cobalamin, Flavin mononucleotide, Folate, Methylmalonic acid, N1-methylnicotinamide, Nicotinamide, Nicotinic acid, Pyridoxal, Pyridoxal 5-phosphate, Pyridoxine, Riboflavin, Thiamine, Thiamine monophosphate, Total homocysteine

Fat-soluble vitamins: 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, α-Tocopherol (Vit. E), All-trans retinol (Vit. A), Phylloquinone (Vit. K1), y-Tocopherol (Vit. E)

Essential amino acids: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

Meat and fish intake: 1-Methylhistidine, 3-Methylhistidine, B-Alanine, Creatine, Creatinine, TMAO

Tobacco use and coffee intake: Cotinine, Trans-3-hydroxycotinine, Trigonelline

Volume (μl)
Analytical techniques
GC- and LC-MS/MS
GC- and LC-MS/MS
GC- and LC-MS/MS
Turnaround time (weeks)

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