BEVITAL AS

High-Precision Metabolomics

 & Proteomics

Decoding Metabolism’s Impact on Health, Disease and Quality of Life
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& Proteomics

High-Precision Metabolomics


Decoding Metabolism's Impact on Health, Disease and Quality of Life
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From Scientists for Scientists

High-Precision Metabolomics

Bevital´s analytical platforms are designed with authentic isotope-labelled internal standards for each analyte, ensuring the highest precision, reliability and statistical power for targeted metabolomics and validation studies.

Physiological Concentration Ranges

Bevital’s diverse analytical platforms allow quantification at physiologically relevant dynamic ranges from pmol/L to mmol/L in various sample matrices as serum, plasma or CSF. Consequently, Bevital’s metabolomics methods typically result in very few missing data points.

Highly Reliable Quantification

Bevital’s methods ensure highly accurate and reproducible quantification. Our participation in external programs (DEKS, DEQAS, KEQAS, ERNDIM and LABQUALITY) are part of our quality control, guaranteeing the highest standards from sample storage to data delivery.

Complete Metabolomic Pathways

Bevital’s pathway panels include dietary biomarkers, metabolic intermediates, vitamins, and derived co‑factors, offering a comprehensive view of the targeted metabolomics network, including potential avenues for crosstalk with other pathways. We also offer customization of panels to meet specific research needs.

Fast-Tracked Academic Support

Bevital is providing academic support from writing of funding applications and critical review of draft manuscripts to statistical analyses. As a non‑profit organization, Bevital offers short‑turnaround, high‑quality analyses at competitive prices, ensuring that researchers receive timely, publication‑ready results without excessive costs.

20+ Years of Experience

Bevital’s staff has participated in numerous scientific projects, gaining extensive experience in developing bio‑analytical technologies and applying them in large‑scale epidemiological studies. Our workflow is designed for optimal sample handling, considering pre‑analytical stability, matrix effects, and minimal sample consumption.

Ready-to-Run

Bevital’s analytical repertoire has been thoughtfully and strategically developed, focusing on established biomarkers, specific metabolites, metabolic classes, and key pathways. We offer four pre-designed analytical panels addressing cardiometabolic functions, inflammation and immune activation, gut microbiome health, nutritional and lifestyle markers.

Cardiometabolic

•Acylcarnitines
•AGEs
•Amino acids & catabolites
•Ketone bodies
•TCA metabolites

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Inflammation & Immune Activation

•Kynurenines & ratio-
 derived metabolites
•Neopterin
•Protein markers


Learn more

Microbiome

•Amino acid derived
 metabolites
•Choline oxidation
•Indoles
•SCFAs

Learn more

Nutrition & Lifestyle

•B- & fat-soluble vitamins
•Essential amino acids
•Meat & fish intake
•Tobacco use & coffee
 intake

Learn more

Compare Panels

Cardiometabolic

•Acylcarnitines
•AGEs
•Amino acids and catabolites
•Ketone bodies
•TCA metabolites

Learn more

Inflammation &
Immune Activation

•Kynurenines and ratio-derived metabolites
•Neopterin
•Proteins
(under development)



Learn more

Microbiome

•Amino acid derived metabolites
•Choline oxidation
•Indoles
•SCFAs


Learn more

Nutrition & Lifestyle

•B- and fat- soluble vitamins
•Essential amino acids
•Meat & fish intake
•Tobacco use & coffee intake


Learn more

Mix-and-Match

Mix and match any markers from our comprehensive portfolio to create a fully customized panel tailored precisely to your research needs, maximizing flexibility and cost-efficiency.

Metabolites, intermediates, vitamins, and co-factors are organized into various categories and can be combined with any individual marker or panel. Our methods have been thoroughly validated and published in high-impact journals.

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Not Found What You Are Looking For?

Contact Our Experts.

Analytes not listed in our analytical repertoire may be included into existing panels and be analysed by customized assays. Discuss your needs with our team to explore tailored strategies for your project. We evaluate proposals based on key factors:

 

  • Classes and types of compounds
  • Number of samples
  • Sample matrix
  • Time frame
  • Published analytical methods
Let´s Discuss Your Project

Multiomics Services

Olink
Biogenity

Bevital is a service provider of Olink® and offers 16 different Olink® Target 96&48 panels for high-quality proteomics from 1 µl of sample volume only.

For larger flexibility customers can choose from about 200 proteins and combine them in unique Olink® Flex panels, offering 5 to 30 assays per kit.

Bevital partners with Biogenity, a research organization specializing in omics research and discovery. With Biogenity’s expertise in biostatistics, Bevital provides a seamless workflow from multi-omics project planning to data integration and interpretation. This collaboration enables our customers to expand their projects by incorporating additional omics data, such as transcriptomics and genomics.

Learn more
Learn more

Multiomics Services

Olink

Bevital is a service provider of Olink® and offers 16 different Olink® Target 96&48 panels for high-quality proteomics from 1 µl of sample volume only.

For larger flexibility customers can choose from about 200 proteins and combine them in unique Olink® Flex panels, offering 5 to 30 assays per kit.

Learn more
Biogenity

Bevital partners with Biogenity, a research organization specializing in omics research and discovery. With Biogenity’s expertise in biostatistics, Bevital provides a seamless workflow from multi-omics project planning to data integration and interpretation. This collaboration enables our customers to expand their projects by incorporating additional omics data, such as transcriptomics and genomics.

Learn more

Testimonials

"I have worked with colleagues at Bevital for many years looking at biomarkers associated with health and potentially cancer in the Melbourne Collaborative Cohort Study. The scientists at Bevital are great to work with in terms of contributing to study design (selecting which markers to measure) and grant applications, analysing the results and writing these up. They have the expertise to complement our epidemiological skills. Logistically, sending samples from Australia has not caused any issues and the whole process of sending samples and receiving our data has gone smoothly. The costs are fair, especially in a collaborative arrangement where we benefit more from Bevital’s experience and the data can be put to additional use by the Bevital team."
Allison HodgeCancer Epidemiology Division, Cancer Council Victoria, Australia
"The HUNT Research Centre, Department of Public Health and Nursing, NTNU, has been involved in an international consortium in cancer research (LC3). Relevant biomarkers were analyzed by Bevital. We are very satisfied with the collaboration with the laboratory, they had thorough quality procedures, deliveries as agreed upon, in addition to helpful contributions to quality classification of blood samples of HUNT participants."
HUNT Research CentreDepartment of Public Health and Nursing, NTNU, Norway
"My research group has been using the excellent services of Bevital. Their performance on quality control is superb and provide consistent results on a number of panels of analytes for our research projects. The cost of services is reasonably low and much lower than some of other labs we used. People at Bevital are very responsive and very pleasant to work with. Their services are excellent and the delivery always on time. I have recommended the Bevital services to several of many colleague who ended up using the Bevital service with great satisfaction. I encourage to check out the Bevital's panels of unique analytes which may benefit your research projects."
Jian-Min YuanCancer Epidemiology and Prevention UPMC Hillman Cancer Center, Pittsburgh, USA

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Per Christian Eriksen

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Beate

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Øivind

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Per Magne Ueland has been Professor at the University of Bergen 1987-2018. He is one of the founders of Bevital AS and the scientific advisor in Bevital since 2023. His interests includes biomarkers related to nutrition, inflammation, ageing and life-style related chronic diseases. Per is committed to the development of precise, high-throughput mass spectrometry methods, tailored for metabolic profiling of biobank specimens from large cohorts.

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Ove completed his education in Biomedical Science at the Western Norway University of Applied Sciences, supplemented by specialized training in Electrical Engineering and Electronics at the Royal Norwegian Naval Training Establishment and the National Institute of Technology. With many years of experience as a biomedical scientist in hospital laboratories—specializing primarily in microbiology—he brings a unique blend of clinical and technical expertise to his work. Ove focuses on the design and prototyping of electronics, as well as the service and maintenance of laboratory instrumentation, ensuring that technical equipment and workflows remain precise and reliable for research-focused activities.

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Lena holds a master’s degree in biology from the University of Bergen, where her thesis focused on identifying whale skeletons using zooarchaeology by mass spectrometry (ZooMS). At Bevital, she works with LC‑MS/MS analyses and method development, focusing on accurate and reliable testing of biological samples. She is dedicated to ensuring precise and high‑quality results that contribute to reliable scientific outcomes and support ongoing research efforts.

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Marit holds a degree in chemical engineering from Bergen Ingeniørhøyskole, which is now part of the Western Norway University of Applied Sciences. She works with quantitative analysis and method development on LC-MS/MS at the laboratory of Bevital AS.

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Randi holds a Master of Science in Chemical Process Engineering from the Norwegian University of Science and Technology (NTNU). She has been part of Bevital since its very beginning, contributing her expertise primarily to the LC-MS/MS platforms, but also to the microbiological assays. In 2021, she stepped into the role of Manager/CEO, where she is dedicated to strengthening Bevital’s innovative profile and ensuring the company’s continued growth and success. She is especially motivated by advancing research that improves health insights and by fostering collaboration that drives scientific and technological progress.

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Ove completed a bachelor’s degree in Biomedical Laboratory Sciences at the Western Norway University of Applied Sciences in Bergen. With extensive experience in method development and expertise in GC-MS/MS, he specializes in optimizing analytical techniques for research-focused studies. At Bevital, Ove is dedicated to advancing laboratory methods and workflows, contributing to innovative research through precise and reliable analytical solutions.

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Lene holds a bachelor’s degree in Biomedical Laboratory Science from the Western Norway University of Applied Sciences, where she is also completing her master’s degree in Medical Laboratory Technology, expected to graduate in 2026. Her master’s thesis focuses on method validation in fatty acid analysis. At Bevital, she works with GC-MS/MS analyses, routinely performing SCFA measurements and emphasizing accurate and reliable testing of biological samples. With her strong laboratory background, Lene is committed to delivering high-quality results that support medical research.

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Klaus earned his PhD in physics from the University of Münster in Germany. For more than thirty years he has specialized in Time‑of‑Flight mass spectrometry, contributing innovative approaches to SNP genotyping and protein quantification. Together with his colleague Lene Njåstad, he oversees Bevital’s Olink Proteomics service. He also leads Bevital’s website and media design efforts, ensuring a clear and informative public presence.

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Adrian holds a PhD in diabetes research, along with bachelor’s and master’s degrees in biomedical science and public health, respectively. With over 20 years of experience in laboratory science, he leads high-precision metabolite analyses and method development at Bevital. His expertise centers on quantifying biomarkers, metabolite classes, and metabolic pathways related to nutrition, cardiovascular and neurodegenerative diseases, and cancer. Adrian is committed to advancing research quality and actively collaborates nationally and internationally, leveraging targeted metabolomics to support innovative, multidisciplinary research.

Statistical power is the probability that a statistical test will correctly reject a false null hypothesis (H0​) when a specific alternative hypothesis (H1​) is true. H0​ is the null hypothesis, which states there is no effect or no difference. H1​ is the alternative hypothesis, which states there is a real effect or difference. Alpha (α) is the probability of a Type I error (a false positive), which is the risk of incorrectly rejecting the H0​ when it is actually true. You set this value before the experiment, commonly at 0.05. Beta (β) is the probability of a Type II error (a false negative), which is the risk of failing to reject the H0​ when it is actually false.

Power is calculated as 1−β. Increasing power means you are decreasing the probability of making a Type II error.

Several factors can be adjusted to increase the power of a statistical test:

  • Effect Size: This is the magnitude of the difference you are trying to detect. A larger effect size is easier to detect, thus increasing power. 

  • Sample Size: The number of observations in a study. A larger sample size provides more information about the population, reducing the margin of error and increasing the power to detect a true effect.

  • Variation: Refers to the spread or standard deviation of the data within the population. Less variation makes it easier to distinguish a real effect from random noise, thereby increasing power.

  • Alpha (): Increasing the alpha level (e.g., from 0.05 to 0.10) also increases power, but at the cost of a higher risk of a Type I error. This trade-off is often undesirable.

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1.

Walzik, David; Wenzel, Charlotte; Strotkötter, Jule Elisabeth; Hoenen, Leon; Chirino, Tiffany Y Wences; Trebing, Sina; McCann, Adrian; Ueland, Per Magne; Zimmer, Philipp; Joisten, Niklas

Systemic metabolite kinetics mirror skeletal muscle energy metabolism during acute aerobic exercise Journal Article

In: Am J Physiol Cell Physiol, vol. 330, no. 1, pp. C111–C118, 2026, ISSN: 1522-1563.

Abstract | Links | BibTeX

2.

Klaassen-Dekker, Niels; Zoetendal, Erwin G; Capuano, Edoardo; Winkels, Renate M; van Duijnhoven, Fränzel Jb; van Heek, N Tjarda; Kruyt, Flip M; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; de Wilt, Johannes Hw; Kampman, Ellen; Kok, Dieuwertje E

Preoperative plasma short- and branched-chain fatty acids in relation to risk of complications after colorectal cancer surgery: a prospective cohort study Journal Article

In: Am J Clin Nutr, vol. 122, no. 6, pp. 1579–1590, 2025, ISSN: 1938-3207.

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3.

Linde, Anja; Gerdts, Eva; Fevang, Bjørg T; Ulvik, Arve; Ueland, Per M; Meyer, Klaus; Kringeland, Ester; Midtbø, Helga

Factors associated with left ventricular mass during disease modifying antirheumatic drug therapy in patients with rheumatoid arthritis: the Joint Heart study Journal Article

In: Int J Cardiol Cardiovasc Risk Prev, vol. 27, pp. 200521, 2025, ISSN: 2772-4875.

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4.

Wenzel, Charlotte; Walzik, David; Wences, Tiffany; Trebing, Sina; Meyer, Klaus; Groll, Andreas; Zimmer, Philipp; Joisten, Niklas

Immunological Protein Signature During Acute Exercise Journal Article

In: Acta Physiol (Oxf), vol. 241, no. 12, pp. e70125, 2025, ISSN: 1748-1716.

Links | BibTeX

5.

Kvestad, Ingrid; Ulak, Manjeswori; McCann, Adrian; Chandyo, Ram K; Hysing, Mari; Schwinger, Catherine; Ranjitkar, Suman; Ueland, Per Magne; Basnet, Sudha; Strand, Tor A

The effect of vitamin B12 supplementation during pregnancy on early motor performance. Secondary analyses from a double-blinded randomized controlled trial Journal Article

In: J Nutr, pp. 101305, 2025, ISSN: 1541-6100.

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6.

Kupjetz, Marie; Langeskov-Christensen, Martin; Riemenschneider, Morten; Inerle, Stefan; Ligges, Uwe; Gaemelke, Tobias; Patt, Nadine; Bansi, Jens; Gonzenbach, Roman Rudolf; Reuter, Marcel; Rosenberger, Friederike; Meyer, Tim; McCann, Adrian; Ueland, Per Magne; Eskildsen, Simon Fristed; Nygaard, Mikkel Karl Emil; Joisten, Niklas; Hvid, Lars; Dalgas, Ulrik; Zimmer, Philipp

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 12, no. 6, pp. e200461, 2025, ISSN: 2332-7812.

Abstract | Links | BibTeX

7.

Sandvig, Heidi Vihovde; Saltvedt, Ingvild; Edwin, Trine Holt; Aam, Stina; Alme, Katinka Nordheim; Eldholm, Rannveig Sakshaug; Lydersen, Stian; Mollnes, Tom Eirik; Munthe-Kaas, Ragnhild; Ueland, Per Magne; Ulvik, Arve; Wethal, Torgeir; Knapskog, Anne-Brita

Associations between systemic inflammation and cognitive trajectories post-stroke Journal Article

In: Sci Rep, vol. 15, no. 1, pp. 42791, 2025, ISSN: 2045-2322.

Abstract | Links | BibTeX

8.

Knudsen, Andreas Dehlbæk; Gelpi, Marco; Suarez-Zdunek, Moises A; Loft, Josefine A; Ueland, Per Magne; Ostrowski, Sisse Rye; Midttun, Øivind; Martinez, Esteban; Nielsen, Susanne D

Inhibition of Th1-type immune responses in persons with HIV with current statin exposure Journal Article

In: AIDS, 2025, ISSN: 1473-5571.

Abstract | Links | BibTeX

9.

Bråtveit, Marianne; Strømland, Pouda P; Laupsa-Borge, Johnny; Skumsnes, Lillian; Dagsland, Vigdis H; Kvistad, Silje; Vogt, Elinor C; McCann, Adrian; Thorsen, Håvard L; Diamantopoulos, Andreas P; Nedrebø, Bjørn Gunnar; Mellgren, Gunnar; Dankel, Simon N

A Very-Low Energy Fast Involves Increased Adipose Inflammatory Gene Expression: A 6-Day Feeding Trial (FASTOMICS-6) Journal Article

In: J Clin Endocrinol Metab, 2025, ISSN: 1945-7197.

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10.

Dhar, Indu; Svingen, Gard Ft; Ulvik, Arve; Bjørnestad, Espen Ø; Sagen, Jørn V; Nygård, Ottar K

Serum Vitamin A Is Associated with Variations in the Relationship between Plasma B6 Vitamers and Cardiovascular Disease Risk Journal Article

In: J Nutr, 2025, ISSN: 1541-6100.

Abstract | Links | BibTeX

11.

Jørgensen, Silje F; Braadland, Peder R; Ueland, Thor; Fraz, Mai S A; Michelsen, Annika E; Holm, Kristian; Osnes, Liv T; Trøseid, Marius; Ueland, Per Magne; Fevang, Børre; Aukrust, Pål; Hov, Johannes R

Tryptophan-kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency Journal Article

In: J Allergy Clin Immunol, vol. 156, no. 3, pp. 814–824.e11, 2025, ISSN: 1097-6825.

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12.

Vilar, Ana; Bayes-Marin, Ivet; Álvarez-Salazar, Samantha; Piqueras-Marques, Jorge; Vila, Santiago Batlle; Forero, Carlos G

Prevalence of depressive symptoms in the general population with a fully structured interview with skips vs. unconditional sequential assessment: implications for clinical and psychiatric epidemiology studies Journal Article

In: J Psychiatr Res, vol. 189, pp. 424–434, 2025, ISSN: 1879-1379.

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13.

Bjørkevoll, Sol Maja G; O'Keeffe, Maria; Konijnenberg, Carolien; Solvik, Beate S; Sødal, Alida F; Kaldenbach, Siri; McCann, Adrian; Ueland, Per M; Kvestad, Ingrid; Ersvær, Elisabeth; Holten-Andersen, Mads N; Bakken, Kjersti S; Strand, Tor A

Infant vitamin B12 status and its predictors - cross-sectional baseline results from an ongoing randomized controlled trial Journal Article

In: Am J Clin Nutr, vol. 122, no. 3, pp. 803–810, 2025, ISSN: 1938-3207.

Abstract | Links | BibTeX

14.

Holthuijsen, Daniëlle D B; van Roekel, Eline H; Bours, Martijn J L; Ueland, Per M; Breukink, Stéphanie O; Janssen-Heijnen, Maryska L G; Konsten, Joop L; Keulen, Eric T P; McCann, Adrian; Brezina, Stefanie; Gigic, Biljana; Kok, Dieuwertje E; Ulrich, Cornelia M; Weijenberg, Matty P; Eussen, Simone J P M

Modeling how iso-caloric macronutrient substitutions are longitudinally associated with plasma kynurenines in colorectal cancer survivors up to 12 months post-treatment Journal Article

In: J Nutr Biochem, vol. 141, pp. 109910, 2025, ISSN: 1873-4847.

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Valim, Valéria; Oliveira, Fabíola R; Miyamoto, Samira T; Serrano, Érica V; Balarini, Gabriela M; Tanure, Leandro A; Ferreira, Gilda A; Zandonade, Eliana; Brun, Johan G; Jonsson, Malin; Maeland, Elisabeth; Ulvik, Arve; Ueland, Per Magne; Jonsson, Roland; Mydel, Piotr M

Kynurenines and neopterin are interferon-gamma-inducible biomarkers for Sjögren's disease Journal Article

In: Rheumatology (Oxford), vol. 64, no. 7, pp. 4404–4413, 2025, ISSN: 1462-0332.

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16.

Bakker, Lieke; Ramakers, Inez H G B; van Greevenbroek, Marleen M J; Backes, Walter H; Jansen, Jacobus F A; Schram, Miranda T; van der Kallen, Carla J H; Schalkwijk, Casper G; Wesselius, Anke; Ulvik, Arve; Ueland, Per M; Verhey, Frans R J; Eussen, Simone J P M; Köhler, Sebastian

The kynurenine pathway and markers of neurodegeneration and cerebral small vessel disease: The Maastricht Study Journal Article

In: J Neurol Sci, vol. 474, pp. 123522, 2025, ISSN: 1878-5883.

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Gordon, Shane; Hoey, Leane; McNulty, Helene; Keenan, Jordan; Pangilinan, Faith; Brody, Lawrence C; Ward, Mary; Strain, J J; McAnena, Liadhan; McCann, Adrian; Molloy, Anne M; Cunningham, Conal; McCarroll, Kevin; Hughes, Catherine F

Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction Journal Article

In: BMC Med, vol. 23, no. 1, pp. 440, 2025, ISSN: 1741-7015.

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18.

Belen, Sergen; Patt, Nadine; Kupjetz, Marie; Ueland, Per M; McCann, Adrian; Gonzenbach, Roman; Bansi, Jens; Zimmer, Philipp

Vitamin B status is related to disease severity and modulated by endurance exercise in individuals with multiple sclerosis: a secondary analysis of a randomized controlled trial Journal Article

In: Am J Clin Nutr, vol. 121, no. 6, pp. 1403–1414, 2025, ISSN: 1938-3207.

Abstract | Links | BibTeX

19.

Dahl, Tuva B; Aftab, Friha; Prebensen, Christian; Berdal, Jan-Erik; Ueland, Thor; Barratt-Due, Andreas; Riise, Anne Ma Dyrhol; Ueland, Per Magne; Hov, Johannes R; Trøseid, Marius; Aukrust, Pål; Gregersen, Ida; Myhre, Peder L; Omland, Torbjørn; Halvorsen, Bente

Imidazole propionate is increased in severe COVID-19 and correlates with cardiac involvement Miscellaneous

2025, ISSN: 1532-2742.

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20.

Park, Jin Young; Puyvelde, Heleen Van; Regazzetti, Lea; Clasen, Joanna L; Heath, Alicia K; Eussen, Simone; Ueland, Per Magne; Johansson, Mattias; Biessy, Carine; Zamora-Ros, Raul; Huerta, José María; Sánchez, Maria-Jose; Ocke, Marga; Schulze, Matthias B; Schiborn, Catarina; Braaten, Tonje Bjørndal; Skeie, Guri; Sacerdote, Carlotta; Castilla, Jesús; Karlsson, Therese; Johansson, Ingegerd; Kyrø, Cecilie; Tjønneland, Anne; Tong, Tammy Y N; Katzke, Verena; Bajracharya, Rashmita; Lasheras, Cristina; Midttun, Øivind; Vollset, Stein Emil; Vineis, Paolo; Masala, Giovanna; Amiano, Pilar; Tumino, Rosario; Baldassari, Ivan; Weiderpass, Elisabete; Riboli, Elio; Gunter, Marc J; Freisling, Heinz; Rinaldi, Sabina; Muller, David C; Huybrechts, Inge; Ferrari, Pietro

Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition Journal Article

In: Nutrients, vol. 17, no. 12, 2025, ISSN: 2072-6643.

Abstract | Links | BibTeX

579 entries « ‹ 1 of 29 › »

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Mix-and-Match

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