Assessment of Disease Risk by Targeted Metabolomics

Assessment of Disease Risk
by Targeted Metabolomics
Updated 7 days ago

Download list of biomarkers here

Vitamins & Lifestyle

B vitamins, folate and cobalamin, fat soluble vitamins, tobacco and coffee, meat and fish intake.

Metabolites & Pathways

AGEs, amino acids and metabolites, acylcarnitines, choline oxidation pathway, citric acid cycle, microbiota derived, one carbon metabolism, transsulfuration, tryptophan metabolites, urea cycle, others.

Pathologies & Physiology

Diabetes, endothelial function, inflammation, keton bodies, liver pathology, neuroactive, oncometabolites, renal function, uremic toxin.

Platforms are organized according the letters A – I


A: Short-chain fatty acids.
B: Amino and carboxylic acids. TCA metabolites and intermediates.


C: Choline derivatives. Charged, methylated or sulfur amino acids.
     Short-chain acylcarnitines.
D: Kynurenine pathway and B vitamins.
E: Folate species and catabolites.
H: Lipid-soluble vitamins and long-chain acylcarnitines.
I: Short-, medium-, and long-chain acylcarnitines (under development).


G: Protein biomarkers (C-reactive protein, serum amyloid A, calprotectin, cystatin C) and their proteoforms. HbA1c.

Microbiological assay

F: Folate and cobalamin.


BEVITAL will soon offer Olink® Target 96 & 48 panels for high quality proteomics.


Our Services

Platform selection

Choice of biomarker panels and analytical platforms can be crucial for the project outcome. Our experts will help you by a pre-analytical evaluation to maximise data quality and quantity at minimal sample consumption.

Data report

Customers receive a detailed report including metabolite concentrations, LODs, missing data diagnosis, quality controls, CVs, and basic data plots.

Data analysis

We offer academic support by our scientists using sophisticated statistical methods based on R and Shiny apps.


Our website provides detailed information about all offered biomarkers, metabolites and pathways, and pre-analytical stability including pdfs of scientific articles.

High precision data including low abundance biomarkers by targeted metabolomics and use of authentic isotope-labelled internal standards

Disease related biomarkers and comprehensive coverage of whole pathways

More than 25 years of experience in chromatography and mass spectrometry

Scientific support from analysis planning to data interpretation

Track record in international, EU-, and NIH-funded projects

Competitive pricing due to low costs

The serum kynurenine pathway metabolic profile is associated with overweight and obesity in multiple sclerosis
Marie Kupjetz et al., Mult Scler Relat Disord. 2023 Mar 1;72:104592. Online ahead of print.
Cystatin C proteoforms in chronic kidney disease
Helene Dahl et al., PLoS One. 2023 Feb 1;18(2):e0269436.
Systemic Activation of the Kynurenine Pathway in Graves` Disease with and without Ophthalmopathy
Hans Olav Ueland et al., J Clin Endocrinol Metab. 2023 Jan 6 Online ahead of print.
Cohort profile: Biomarkers related to folate-dependent one-carbon metabolism in colorectal cancer recurrence and survival - the FOCUS Consortium
Biljana Gigic et al., BMJ Open. 2022 Dec 22;12(12)
Longitudinal Associations of Adherence to the Dietary World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) and Dutch Healthy Diet (DHD) Recommendations with Plasma Kynurenines in Colorectal Cancer Survivors after Treatment
Daniëlle D B Holthuijsen et al., Nutrients. 2022 Dec 3;14(23):5151.
Inflammation, sex, blood pressure changes and hypertension in midlife: the Hordaland Health Study
Ester Kringeland et al., J Hum Hypertens. 2022 Nov 18. Online ahead of print.
A cross-sectional study of inflammatory markers as determinants of circulating kynurenines in the Lung Cancer Cohort Consortium
Øvind Midttun et al., Sci Rep. 2023 Jan 18;13(1):1011.
The Influence of Preanalytical Biospecimen Handling on the Measurement of B Vitamers, Amino Acids, and Other Metabolites in Blood
Kara A Michels et al., Biopreserv Biobank. 2023 Jan 9. Online ahead of print.
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip fracture patients
Leiv Otto Watne et al., J Clin Invest. 2023 Jan 17;133(2)
Assessment of vitamin B6 status in never-pregnant, pregnant and postpartum women and their infants
Anne-Lise Bjørke-Monsen et al., Eur J Nutr. 2022 Nov 1. Online ahead of print.
Stable isotope ratios of nitrogen and carbon as biomarkers of a vegan diet
Jutta Dierkes et al., Eur J Nutr. 2023; 62(1): 433–441.
Plasma methylmalonic acid predicts risk of acute myocardial infarction and mortality in patients with coronary heart disease: A prospective 2-cohort study
Indu Dhar et al., J Intern Med. 2023 Jan 22. Online ahead of print.
Serum concentrations of amino acids and tryptophan metabolites are affected by consumption of a light breakfast: a clinical intervention study in adults with overweight or obesity
Ingrid V Hagen et al., BMC Nutr. 2023 Jan 11;9(1):10.
Changes in Tryptophan-Kynurenine Metabolism in Patients with Depression Undergoing ECT-A Systematic Review
Tore I M Aarsland et al., Pharmaceuticals. 2022 Nov 19;15(11),1439.
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging
Stein-Erik H Solvang et al., Oxid Med Cell Longev. 2022 Oct 21. eCollection 2022.
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
Joanna L Clasen et al., Int J Cancer. 2022 Sep 1;151(5):708-716. Epub 2022 Apr 16.
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Publications since 2007

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