Key-data
Multianalyte determination is carried out in a single aliquot. Volume requirement is independent of the number of metabolites. ”Reported values” are not strictly ”normal reference range”, which depends on the population, and several factors, including age, gender, ethnicity and procedures for sample handling and analytical technology. ”Reported values” are concentrations that we and others have observed or reported for serum/plasma in various cohorts. The metabolites are grouped into classes.
BEVITAL platforms A – I
- A
- B
- C
- D
- E
- F
- G
- H
- I
- All
TCA metabolites and intermediates. Short-chain fatty acids.
Volume: 50-200 µL
All concentrations are reported as µmol/L; move cursor over header for more information.
Metabolites | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix |
---|---|---|---|---|---|---|---|---|---|
Citrate | Cit | Tricarboxylic acid | 311 | 90-200 | s, p | ||||
Isocitrate | iCit | Tricarboxylic acid | 1198 | 2-22 | s, p, csf | ||||
α-Ketoglutarate | aKG | Keto acid | 51 | 2-40 | s, p, csf | ||||
Fumarate | Fum | Dicarboxylic acid | 444972 | 0.5-4 | s, p, csf | ||||
Malate | Mal | β-Hydroxy acid | 525 | 2-21 | s, p, csf | ||||
Pyruvate | Pyr | α-Keto acid | 1060 | 80-160 | s, p, csf | ||||
Lactate | Lac | α-Hydroxy acid | 612 | 500-1600 | s, p, csf | ||||
Formate | Frm | Short-chain fatty acid | 284 | 8-100 | s, p, csf | ||||
Acetate | Ace | Short-chain fatty acid | 175-176 | 80-300 | s, p | ||||
Propionate | Pro | Short-chain fatty acid | 1042 | 1-13 | s, p | ||||
Butyrate | But | Short-chain fatty acid | 264 | 1-30 | s, p | ||||
Isobutyrate | iBut | Short-chain fatty acid | 6590 | 0.7-6 | s, p, csf | ||||
Valerate | Vlr | Short-chain fatty acid | 7991 | 0.2-1 | s, p | ||||
Isovalerate | iVlr | Short-chain fatty acid | 10430 | 0.3-3 | s, p | ||||
α-Methylbutyrate | aMB | Short-chain fatty acid | 8314 | 0.3-3 | s, p |
Amino- and carboxylic acids.
Volume: 50-200 µL
All concentrations are reported as µmol/L; move cursor over header for more information.
*Sarcosine cannot be measured in EDTA-tubes from some suppliers because of the presence of sarcosine in these tubes; **BCAA, Branched chain amino acid; ***AGE, Advanced glycation end product.
Choline derivatives. Charged, methylated or sulfur amino acids. Short- and medium-chain acylcarnitines.
Volume: 50-200 µL
All concentrations are reported as µmol/L; move cursor over header for more information.
*Measured in a separate assay after sample treatment with phospholipase D that does not affect the other metabolites of platform C, which are obtainable; **Measured in a separate assay involving alkaline hydrolysis of acylcarnitines.
Kynurenine pathway and B vitamins (B1, B2, B3, B6).
Volume: 60-200 µL
All concentrations are reported as µmol/L or nmol/L; move cursor over header for more information.
Folate species and catabolites.
Volume: 60-200 µL
All concentrations are reported as nmol/L; move cursor over header for more information.
Folate (B9) and cobalamin (B12).
Volume: 20-100 µL
Move cursor over header for more information.
Protein biomarkers and variants. Volume: 30-60 µL
Move cursor over header for more information. *One mass interference of S100A and CnC proteoforms; **ICCs of proteoforms can be found here
Lipid-soluble vitamins and long-chain acylcarnitines.
Volume: 50-200 µL
All concentrations are reported as µmol/L or nmol/L; move cursor over header for more information.
This platform is under development.
Short-, medium- and long-chain acylcarnitines.
Volume: 50-200 µL
All concentrations are reported as µmol/L; move cursor over header for more information.
Metabolites | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix |
---|---|---|---|---|---|---|---|---|---|
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 | 0.2 | s, p | |||
Carnitine | C0 | Carnitine | 288 | 20-80 | 0.5 | np | s, p | ||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 | 0.1 | 0.63 | s, p | ||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 | 0.05 | 0.62 | s, p | ||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 | 0.012 | s, p | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 | 0.05 | 0.68 | s, p | ||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 | 0.01 | s, p | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 | 0.05 | 0.41 | s, p | ||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 | 0.02 | s, p | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 | 0.02 | s, p | |||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 | na | na | na | 0.38 | s, p |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 | na | na | na | 0.49 | s, p |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 | na | na | na | 0.40 | s, p |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 | na | na | na | s, p | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 | na | na | na | s, p |
All biomarkers sorted by platform
Move cursor over header for more information.
Biomarkers | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix | Platform |
---|---|---|---|---|---|---|---|---|---|---|
Citrate | Cit | Tricarboxylic acid | 311 | 90-200 µmol/L | s, p | A | ||||
Isocitrate | iCit | Tricarboxylic acid | 1198 | 2-22 µmol/L | s, p, csf | A | ||||
α-Ketoglutarate | aKG | Keto acid | 51 | 2-40 µmol/L | s, p, csf | A | ||||
Fumarate | Fum | Dicarboxylic acid | 444972 | 0.5-4 µmol/L | s, p, csf | A | ||||
Malate | Mal | β-Hydroxy acid | 525 | 2-21 µmol/L | s, p, csf | A | ||||
Pyruvate | Pyr | α-Keto acid | 1060 | 80-160 µmol/L | s, p, csf | A | ||||
Lactate | Lac | α-Hydroxy acid | 612 | 500-1600 µmol/L | s, p, csf | A | ||||
Formate | Frm | Short-chain fatty acid | 284 | 8-100 µmol/L | s, p, csf | A | ||||
Acetate | Ace | Short-chain fatty acid | 175-176 | 80-300 µmol/L | s, p | A | ||||
Propionate | Pro | Short-chain fatty acid | 1042 | 1-13 µmol/L | s, p | A | ||||
Butyrate | But | Short-chain fatty acid | 264 | 1-30 µmol/L | s, p | A | ||||
Isobutyrate | iBut | Short-chain fatty acid | 6590 | 0.7-6 µmol/L | s, p, csf | A | ||||
Valerate | Vlr | Short-chain fatty acid | 7991 | 0.2-1 µmol/L | s, p | A | ||||
Isovalerate | iVlr | Short-chain fatty acid | 10430 | 0.3-3 µmol/L | s, p | A | ||||
α-Methylbutyrate | aMB | Short-chain fatty acid | 8314 | 0.3-3 µmol/L | s, p | A | ||||
Methylmalonic acid | MMA | Carboxylic acid | 487 | <0.26 µmol/L | 0.03 | 2.4 | 3 | 0.81 | s, p, u | B |
Total homocysteine | tHcy | Sulfur amino acid | 91552 | 5-15 µmol/L | 0.1 | 1.4 | 2.7 | 0.72 | s, p, u | B |
Total cysteine | tCys | Sulfur amino acid | 5862 | 150-350 µmol/L | 50 | 1 | 2 | 0.62 | s, p, u | B |
Methionine | Met | Essential amino acid | 6137 | 18-50 µmol/L | 1 | 2.2 | 4.1 | 0.33 | s, p, u | B |
Serine | Ser | Polar amino acid | 5951 | 95-125 µmol/L | 5 | 1.3 | 1.7 | 0.71 | s, p, u | B |
Glycine | Gly | Hydrophobic amino acid | 750 | 200-300 µmol/L | 3 | 1.3 | 1.7 | 0.81 | s, p, u | B |
Cystathionine | Cysta | Thioether | 439258 | <0.4 µmol/L | 0.02 | 2.3 | 2.9 | 0.63 | s, p, u | B |
Sarcosine | Sarc | Methylated amino acid | 1088 | 0.7-2.3 µmol/L | 0.035 | 1.3 | 1.6 | 0.68 | s, p, u | B |
Histidine | His | Essential amino acid | 6274 | 50-100 µmol/L | 1 | 2 | 3 | na | s, p, u | B |
Tryptophan | Trp | Essential aromatic amino acid | 6305 | 40-90 µmol/L | 0.1 | 1.6 | 2.6 | 0.51 | s, p, u | B |
Kynurenine | Kyn | Trp metabolite | 161166 | 1.0-3.0 µmol/L | 0.12 | 1.9 | 2.3 | 0.68 | s, p, u | B |
Ornithine | Orn | Charged amino acid | 6262 | 30-90 µmol/L | 1 | 2.2 | 2.7 | s, p, u | B | |
Aspartic acid | Asp | Charged amino acid | 5960 | 0-26 µmol/L | 0.5 | 1.8 | 4 | s, p, u | B | |
Glutamic acid | Glu | Charged amino acid | 33032 | 20-140 µmol/L | 0.5 | 1.7 | 2.7 | s, p, u | B | |
Lysine | Lys | Essential amino acid | 5962 | 120-290 µmol/L | 1.2 | 1.4 | 1.9 | s, p, u | B | |
Alanine | Ala | Hydrophobic amino acid | 5950 | 230-510 µmol/L | 1 | 1.2 | 1.4 | s, p, u | B | |
Phenylalanine | Phe | Essential aromatic amino acid | 6140 | 26-85 µmol/L | 0.5 | 1.5 | 3 | s, p, u | B | |
Isoleucine | Ile | Essential BCAA | 6306 | 40-140 µmol/L | 0.5 | 1.5 | 1.8 | s, p, u | B | |
Leucine | Leu | Essential BCAA | 6106 | 70-170 µmol/L | 0.5 | 3.4 | 4 | s, p, u | B | |
Proline | Pro | Hydrophobic amino acid | 145742 | 110-360 µmol/L | 0.5 | 2.8 | 3.7 | s, p, u | B | |
Valine | Val | Essential BCAA | 6287 | 150-350 µmol/L | 0.5 | 2.2 | 2.7 | s, p, u | B | |
Asparagine | Asn | Polar amino acid | 6267 | 20-130 µmol/L | 0.6 | 3 | 3 | s, p, u | B | |
Glutamine | Gln | Polar amino acid | 5961 | 390-700 µmol/L | 10 | 2.1 | 2.7 | s, p, u | B | |
Threonine | Thr | Essential amino acid | 6288 | 70-240 µmol/L | 1.2 | 2.4 | 3.3 | s, p, u | B | |
Tyrosine | Tyr | Aromatic amino acid | 6057 | 40-110 µmol/L | 0.5 | 2.1 | 2.8 | s, p, u | B | |
α-Hydroxyglutaric acid | aHG | Alfa hydroxy acid | 43 | 0.15-2 µmol/L | s, p, u | B | ||||
3-Hydroxyisobutyrate | 3HIB | Val metabolite | 440873 | 15-25 µmol/L | 3 | 2.4 | 2.9 | s, p, u | B | |
2-Hydroxybutyrate | aHB | Alfa hydroxy acid | 11266 | 10-60 µmol/L | 3 | 1.7 | 2.3 | s, p | B | |
3-Hydroxybutyrate | bHB | Keton body | 441 | 20-700 µmol/L | 3 | 1.9 | 3.4 | s, p | B | |
Acetoacetate | AcAc | Keton body | 96 | 10-200 µmol/L | 5 | s, p | B | |||
Carboxymethyllysine | CML | an AGE | 123800 | 0.05-0.3 µmol/L | 0.03 | s, p | B | |||
Carboxyethyllysine | CEL | an AGE | 23400779 | 0.05-0.4 µmol/L | 0.03 | s, p | B | |||
2-Aminoadipic acid | 2AAA | Lys metabolite | 469 | 0.3-1.8 µmol/L | s, p | B | ||||
β-Aminoisobutyrate | BAIBA | Val metabolite | 64956 | 0.3-2.0 µmol/L | s, p | B | ||||
Beta-alanine | bAla | Beta amino acid | 239 | 0.5-10 µmol/L | s, p | B | ||||
3-Hydroxykynurenine | HK | 11811 | u | B | ||||||
Kynurenic acid | KA | 3845 | u | B | ||||||
Anthranilic acid | AA | 227 | u | B | ||||||
Xanthurenic acid | XA | 5699 | u | B | ||||||
3-Hydroxyanthranilic acid | HAA | 86 | u | B | ||||||
Formiminoglutamic acid | Figlu | 439233 | u | B | ||||||
Choline | Chol | Quarternary ammonium | 305 | 5-15 µmol/L | 0.5 | 2.8 | 3.2 | 0.36 | s, p, u | C |
Choline, total | tChol | Choline esters | 2-3 mmol/L | 0.5 | s, p | C | ||||
Trimethylamine N-oxide | TMAO | Amine oxide | 1145 | 0.5-60 µmol/L | 0.1 | 4 | 4.1 | <0.38 | s, p, u | C |
Betaine | Bet | Methylated amino acid | 247 | 20-60 µmol/L | 0.5 | 3.8 | 4.5 | 0.65 | s, p, u | C |
Dimethylglycine | DMG | Methylated amino acid | 673 | 1.5–5 µmol/L | 0.25 | 5.5 | 5.9 | 0.64 | s, p, u | C |
Total homocysteine | tHcy | Amino acid | 91552 | 6-20 µmol/L | 0.1 | 1 | 2 | 0.72 | s, p, u | C |
Creatine | Crn | Alpha amino acid | 586 | 10-100 µmol/L | 1 | 3.9 | 4 | na | s, p, u | C |
Creatinine | Creat | Alpha amino acid | 588 | 50-100 µmol/L | 0.25 | 2.6 | 3.1 | 0.79 | s, p, u | C |
Methionine | Met | Essential amino acid | 6137 | 18-50 µmol/L | 1 | 4.1 | 4.5 | 0.33 | s, p | C |
Methionine sulfoxide | MetSo | Polar amino acid | 158980 | 0.5-5 µmol/L | 0.06 | 7.1 | 7.9 | 0.36 | s, p | C |
Cystathionine | Cysta | Thioether | 439258 | < 0.4 µmol/L | 0.025 | 6-12 | 7-10 | 0.63 | s, p | C |
Total cysteine | tCys | Sulfur amino acid | 5862 | 150-400 µmol/L | 0.1 | 2 | 6 | 0.56 | s, p | C |
Histidine | His | Essential amino acid | 6274 | 50-100 µmol/L | 0.25 | 3.5 | 3.8 | na | s, p | C |
3-Methylhistidine | 3-MH | Amino acid | 92105 | 2.7-10 µmol/L | 0.6 | 4.4 | 4.9 | na | s, p, u | C |
1-Methylhistidine | 1-MH | Amino acid | 64969 | 0.5-15 µmol/L | 0.25 | 3.7 | 3.9 | na | s, p, u | C |
Citrulline | Ctn | Amino acid | 9750 | 10-60 µmol/L | 4 | 7-8 | 6-9 | na | s, p | C |
Ornithine | Orn | Charged amino acid | 6262 | 30-90 µmol/L | 0.5 | 7-8 | 7-9 | na | s, p | C |
Arginine | Arg | Charged amino acid | 6322 | 40-100 µmol/L | 0.25 | 2.6 | 3 | 0.53 | s, p | C |
Asymmetric dimethylarginine | ADMA | Guanidinated amino acid | 123831 | 0.4-0.8 µmol/L | 0.08 | 5.2 | 5.5 | 0.53 | s, p | C |
Symmetric dimethylarginine | SDMA | Guanidinated amino acid | 169148 | 0.4-0.9 µmol/L | 0.08 | 4.8 | 5.2 | 0.62 | s, p | C |
Homoarginine | hArg | Guanidinated amino acid | 9085 | 1-6 µmol/L | 0.1 | 5.8 | 6 | 0.65 | s, p | C |
Trimethyllysine | TML | Methylated amino acid | 440121 | 0.3-2 µmol/L | 0.2 | 4 | 4.4 | 0.15 | s, p | C |
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 µmol/L | 0.2 | s, p | C | |||
Carnitine | C0 | Carnitine | 288 | 20-80 µmol/L | 0.5 | 0.69 | s, p | C | ||
Carnitine, total | tC0 | Carnitines | 30-90 µmol/L | 0.5 | s, p | C | ||||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 µmol/L | 0.1 | 0.63 | s, p | C | ||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 µmol/L | 0.05 | 0.62 | s, p | C | ||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 µmol/L | 0.012 | s, p | C | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 µmol/L | 0.05 | 0.68 | s, p | C | ||
Glutarylcarnitine | C5DC | Acylcarnitine | 71464488 | < 0.05 µmol/L | 0.01 | s, p | C | |||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 µmol/L | 0.01 | s, p | C | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 µmol/L | 0.05 | 0.41 | s, p | C | ||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 µmol/L | 0.02 | s, p | C | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 µmol/L | 0.02 | s, p | C | |||
Pyridoxal 5'-phosphate | PLP | B6 vitamer | 1051 | 15–150 nmol//L | 0.2 | 3.5 | 5.7 | 0.7 | s, p | D |
7-70 nmol | csf | D | ||||||||
Pyridoxal | PL | B6 vitamer | 1050 | 5–150 nmol/L | 0.2 | 3.5 | 5.1 | 0.62 | s, p | D |
10-50 nmol/L | csf | D | ||||||||
4-Pyridoxic acid | PA | B6 vitamer | 6723 | 10–200 nmol/L | 0.5 | 3.6 | 5.8 | 0.58 | s, p | D |
0-15 nmol/L | csf | D | ||||||||
Pyridoxine | PN | B6 vitamer | 1054 | 0.05 | 4.5 | 5.2 | na | s, p | D | |
Thiamine | Thi | B1 vitamer | 1130 | 2–50 nmol/L | 0.25 | 3.5 | 4.9 | s, p | D | |
5-40 nmol/L | csf | D | ||||||||
Thiamine monophosphate | TMP | B1 vitamer | 1131 | 2–15 nmol/L | 0.5 | 7.1 | 11.6 | s, p | D | |
25-75 µmol/L | csf | D | ||||||||
Riboflavin | Ribo | B2 vitamer | 493570 | 5–100 nmol/L | 0.2 | 6 | 7.1 | 0.79 | s, p | D |
5-25 nmol/L | csf | D | ||||||||
Flavin mononucleotide | FMN | B2 vitamer | 643976 | 3–30 nmol/L | 0.4 | 5.7 | 8.1 | 0.69 | s, p | D |
1-2 nmol/L | csf | D | ||||||||
Cystathionine | Cysta | Thioether | 439258 | <0.4 µmol/L | 0.02 | 3.4 | 4.5 | 0.63 | s, p | D |
Neopterin | Neopt | Pteridine | 4455 | 5-50 nmol/L | 0.7 | 5.3 | 6.6 | 0.6 | s, p | D |
5-50 nmol/L | csf | D | ||||||||
Tryptophan | Trp | Essential aromatic amino acid | 6305 | 40-90 µmol/L | 4 | 3.1 | 3.9 | 0.51 | s, p | D |
2-7 µmol/L | csf | D | ||||||||
Kynurenine | Kyn | Trp metabolite | 161166 | 1.0-3.0 µmol/L | 0.007 | 3.6 | 5.1 | 0.68 | s, p | D |
0.02-0.12 µmol/L | csf | D | ||||||||
Kynurenic acid | KA | Trp metabolite | 3845 | 20-100 nmol/L | 0.4 | 4.4 | 5.4 | 0.68 | s, p | D |
0.5-15 nmol/L | csf | D | ||||||||
Quinaldic acid | Qld | Trp (KA) metabolite | 7124 | 0.2-100 nmol/L | 0.5 | 6-7 | 6-8 | na | s, p | D |
0.1-10 nmol/L | csf | D | ||||||||
Anthranilic acid | AA | Trp metabolite | 227 | 7-30 nmol/L | 0.7 | 7.4 | 9.5 | 0.64 | s, p | D |
3-14 nmol/L | csf | D | ||||||||
3-Hydroxykynurenine | HK | Trp metabolite | 11811 | 25-80 nmol/L | 2 | 3.2 | 4.5 | 0.62 | s, p | D |
0.1-25 nmol/L | csf | D | ||||||||
Xanthurenic acid | XA | Trp metabolite | 5699 | 2-35 nmol/L | 0.5 | 4.8 | 5.7 | 0.58 | s, p | D |
<0.5 nmol/L | csf | D | ||||||||
3-Hydroxyanthranilic acid | HAA | Trp metabolite | 86 | 10-80 nmol/L | 2 | 4.6 | 6 | 0.54 | s, p | D |
0-7 nmol/L | csf | D | ||||||||
Cinnabarinic acid | CBA | Trp (HAA) metabolite | 114918 | 0.5 | na | s, p | D | |||
csf | D | |||||||||
Picolinic acid | Pic | Trp metabolite | 1018 | 20-100 nmol/L | 8 | 6-7 | 5-8 | na | s, p | D |
5-100 nmol/L | csf | D | ||||||||
Quinolinic acid | QA | Trp metabolite | 1066 | 150-700 nmol/L | 1.6 | 7-8 | 7-10 | na | s, p | D |
10-150 nmol/L | csf | D | ||||||||
Nicotinic acid | NA | B3 vitamer | 938 | <20 nmol/L | 10 | 4 | 5.4 | na | s, p | D |
Nicotinamide | NAM | B3 vitamer | 936 | 100-600 nmol/L | 20 | 4.2 | 6.1 | na | s, p | D |
5-200 nmol/L | csf | D | ||||||||
N1-methylnicotinamide | mNAM | B3 vitamer | 457 | 20-250 nmol/L | 5 | 4 | 5.5 | na | s, p | D |
5-100 nmol/L | csf | D | ||||||||
Cotinine | Cot | Nicotine metabolite | 854019 | <3000 nmol/L | 1 | 3 | 4.2 | 0.92 | s, p, u | D |
Trans-3'-hydroxycotinine | OHCot | Nicotine metabolite | 107963 | <1500 nmol/L | 2 | 3.6 | 4.5 | 0.85 | s, p, u | D |
Trigonelline | Trig | Alkaloid | 5570 | <25 µmol/L | 0.01 | 2.9 | 3.8 | 0.66 | s, p | D |
Trimethylamine N-oxide | TMAO | Amine oxide | 1145 | 0.5-60 µmol/L | 4.2 | 6.9 | <0.38 | s, p, u | D | |
0.2-12 µmol/L | csf | D | ||||||||
Imidazole propionate | ImP | Histidine metabolite | 70630 | 3-500 nmol/L | 2 | s, p | D | |||
Urocanate | Uro | Histidine metabolite | 0.1-0.6 µmol/L | s, p | D | |||||
3-Indoxyl sulfate | 3IS | Indole, Trp metabolite | 10258 | 0.9-30 µmol/L | 0.1 | s, p | D | |||
Indole-3-acetamide | IAM | Indole, Trp metabolite | 397 | 0-10 nmol/L | 0.8 | s, p | D | |||
Indole-3-acetate | IAA | Indole, Trp metabolite | 802 | 0.3-23 µmol/L | 0.05 | s, p | D | |||
Indole-3-acetaldehyde | IAAld | Indole, Trp metabolite | 800 | s, p | D | |||||
Indole-3-aldehyde | IAld | Indole, Trp metabolite | 10256 | 0.01-0.20 µmol/L | 4 | s, p | D | |||
Indole-3-lactate | ILA | Indole, Trp metabolite | 92904 | 0.08-5 µmol/L | 0.025 | s, p | D | |||
Indole-3-acrylate | IAcA | Indole, Trp metabolite | 5375048 | s, p | D | |||||
Indole-3-propionate | IPA | Indole, Trp metabolite | 3744 | 0.5-12 µmol/L | 0.02 | s, p | D | |||
5-Methyl-tetrahydrofolate | mTHF | Folate | 439234 | >7.5 nmol/L | 0.07 | 5-9 | 4-5 | na | s, p | E |
5-Formyl-tetrahydrofolate | fTHF | Folate | 6006 | 0-2 nmol/l | 0.52 | 8-9 | 6-11 | na | s, p | E |
Folic acid | FA | Folate | 6037 | 0-2 nmol/L | 0.27 | 7-8 | 6-12 | na | s, p | E |
4-Alfa-hydroxy-5-methyl-THF | hmTHF | Oxidized folate | 0.2 | 6-10 | 6-7 | na | s, p | E | ||
Para-aminobenzoylglutamate | pABG | Folate catabolite | 196473 | 0-0.5 nmol/L | 0.08 | 6-9 | 3-10 | na | s, p | E |
Acetamidobenzoylglutamate | apABG | Folate catabolite | 3080868 | 0.1-1 nmol/L | 0.13 | 5-6 | 5-10 | na | s, p | E |
Serum folate as pABG equivalents | S pABG | Folate | >7.5 nmol/L | s, p | E | |||||
RBC folate as pABG equivalents | E pABG | Folate | >340 nmol/L | e | E | |||||
Serum folate | s-Folate | B-vitamin | >7.5 nmol/L | 2 | 4 | 5 | 0.56 | s, p | F | |
Erythrocyte folate | e-Folate | B-vitamin | >340 nmol/L | e | F | |||||
Serum cobalamin | s-B12 | B-vitamin | >150 pmol/L | 30 | 4 | 5 | 0.82 | s, p | F | |
C-reactive protein | hsCRP | Protein | 0-10 µg/ml | 0.06 | 3-6 | 3-7 | 0.54 | s, p | G | |
Serum amyloid A and variants | SAA | Protein | 0-20 µg/ml | 0.04 | na | s, p | G | |||
Calprotectin and variants | Calp | Protein | 0-30 µg/ml | 0.02 | na | s, p | G | |||
Cystatin C and variants | Cys-C | Protein | 0-8 µg/ml | 0.01 | 3-9 | 5-8 | na | s, p | G | |
HbA1c | HbA1c | Protein | 4-14 % | na | 5 | na | na | w | G | |
All-trans retinol | Vit. A | A vitamer | 445354 | 1.46-2.84 µmol/L | 0.1 | 2.9 | 3.6 | 0.87 | s, p | H |
25-hydroxy vitamin D2 | 25OH-D2 | D vitamer | 5710148 | 0-30 nmol/L | 3.3 | 6.6 | 8.1 | na | s, p | H |
25-hydroxy vitamin D3 | 25OH-D3 | D vitamer | 5283731 | 32.4-98.5 nmol/L | 3.3 | 5.1 | 6.1 | 0.71 | s, p | H |
alpha-tocopherol | aToc | E vitamer | 14985 | 18.9-38.8.0 µmol/L | 2 | 4.3 | 5.8 | 0.86 | s, p | H |
gamma-tocopherol | gToc | E vitamer | 92729 | 2-11 µmol/L | 0.1 | 3.7 | 5 | na | s, p | H |
Phylloquinone | Vit. K1 | K vitamer | 5284607 | 0.1-8.7 nmol/L | 0.5 | 4.8 | 7.4 | 0.49 | s, p | H |
Menaquinone-4 | Vit. K2 | K vitamer | 5282367 | na | na | na | na | H | ||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 µmol/L | na | na | na | 0.38 | s, p | H |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 µmol/L | na | na | na | 0.49 | s, p | H |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 µmol/L | na | na | na | 0.40 | s, p | H |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 µmol/L | na | na | na | s, p | H | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 µmol/L | na | na | na | s, p | H | |
Trimethyllysine | TML | Methylated amino acid | 0.3-2 µmol/L | s, p | I | |||||
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 µmol/L | 0.2 | s, p | I | |||
Carnitine | C0 | Carnitine | 288 | 20-80 µmol/L | 0.5 | s, p | I | |||
Carnitine, total** | tC0 | Carnitines | 30-90 µmol/L | 0.5 | s, p | I | ||||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 µmol/L | 0.1 | s, p | I | |||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 µmol/L | 0.05 | s, p | I | |||
Malonylcarnitine | C3DC | Acylcarnitine | 91825606 | 0.03-0.2 µmol/L | s, p | I | ||||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 µmol/L | 0.012 | s, p | I | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 µmol/L | 0.05 | s, p | I | |||
Glutarylcarnitine | C5DC | Acylcarnitine | 71464488 | < 0.05 µmol/L | 0.01 | s, p | I | |||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 µmol/L | 0.01 | s, p | I | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 µmol/L | 0.05 | s, p | I | |||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 µmol/L | 0.02 | s, p | I | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 µmol/L | 0.02 | s, p | I | |||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 µmol/L | na | na | na | s, p | I | |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 µmol/L | na | na | na | s, p | I | |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 µmol/L | na | na | na | s, p | I | |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 µmol/L | na | na | na | s, p | I | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 µmol/L | na | na | na | s, p | I |
TCA metabolites and intermediates. Short-chain fatty acids.
Volume: 50-200 µL
All concentrations are reported as µmol/L; CVs (%) shown as within-day (Wtn-day) and between-day (Btw-day) variations; sample matrices: serum (s), plasma (p), cerebrospinal fluid (csf).
Metabolites | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix |
---|---|---|---|---|---|---|---|---|---|
Citrate | Cit | Tricarboxylic acid | 311 | 90-200 | s, p | ||||
Isocitrate | iCit | Tricarboxylic acid | 1198 | 2-22 | s, p, csf | ||||
α-Ketoglutarate | aKG | Keto acid | 51 | 2-40 | s, p, csf | ||||
Fumarate | Fum | Dicarboxylic acid | 444972 | 0.5-4 | s, p, csf | ||||
Malate | Mal | β-Hydroxy acid | 525 | 2-21 | s, p, csf | ||||
Pyruvate | Pyr | α-Keto acid | 1060 | 80-160 | s, p, csf | ||||
Lactate | Lac | α-Hydroxy acid | 612 | 500-1600 | s, p, csf | ||||
Formate | Frm | Short-chain fatty acid | 284 | 8-100 | s, p, csf | ||||
Acetate | Ace | Short-chain fatty acid | 175-176 | 80-300 | s, p | ||||
Propionate | Pro | Short-chain fatty acid | 1042 | 1-13 | s, p | ||||
Butyrate | But | Short-chain fatty acid | 264 | 1-30 | s, p | ||||
Isobutyrate | iBut | Short-chain fatty acid | 6590 | 0.7-6 | s, p, csf | ||||
Valerate | Vlr | Short-chain fatty acid | 7991 | 0.2-1 | s, p | ||||
Isovalerate | iVlr | Short-chain fatty acid | 10430 | 0.3-3 | s, p | ||||
α-Methylbutyrate | aMB | Short-chain fatty acid | 8314 | 0.3-3 | s, p |
Amino- and carboxylic acids.
Volume: 50-200 µL
All concentrations are reported as µmol/L; CVs (%) shown as within-day (Wtn-day) and between-day (Btw-day) variations; sample matrices: serum (s), plasma (p), urine (u).
*Sarcosine cannot be measured in EDTA-tubes from some suppliers because of the presence of sarcosine in these tubes; **BCAA, Branched chain amino acid; ***AGE, Advanced glycation end product.
Choline derivatives. Charged, methylated or sulfur amino acids. Short- and medium-chain acylcarnitines.
Volume: 50-200 µL
All concentrations are reported as µmol/L; CVs (%) shown as within-day (Wtn-day) and between-day (Btw-day) variations; sample matrices: serum (s), plasma (p), urine (u).
*Measured in a separate assay after sample treatment with phospholipase D that does not affect the other metabolites of platform C, which are obtainable; **Measured in a separate assay involving alkaline hydrolysis of acylcarnitines.
Kynurenine pathway and B vitamins (B1, B2, B3, B6).
Volume: 60-200 µL
CVs (%) shown as within-day (Wtn-day) and between-day (Btw-day) variations; sample matrices: serum (s), plasma (p), urine (u), cerebrospinal fluid (csf).
Metabolites | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix |
---|---|---|---|---|---|---|---|---|---|
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 | 0.2 | s, p | |||
Carnitine | C0 | Carnitine | 288 | 20-80 | 0.5 | np | s, p | ||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 | 0.1 | 0.63 | s, p | ||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 | 0.05 | 0.62 | s, p | ||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 | 0.012 | s, p | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 | 0.05 | 0.68 | s, p | ||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 | 0.01 | s, p | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 | 0.05 | 0.41 | s, p | ||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 | 0.02 | s, p | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 | 0.02 | s, p | |||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 | na | na | na | 0.38 | s, p |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 | na | na | na | 0.49 | s, p |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 | na | na | na | 0.40 | s, p |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 | na | na | na | s, p | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 | na | na | na | s, p |
Biomarkers | Abbr | Category | PubChem | Reported | LOD | CV Wtn | CV Btw | ICC | Matrix | Platform |
---|---|---|---|---|---|---|---|---|---|---|
Citrate | Cit | Tricarboxylic acid | 311 | 90-200 µmol/L | s, p | A | ||||
Isocitrate | iCit | Tricarboxylic acid | 1198 | 2-22 µmol/L | s, p, csf | A | ||||
α-Ketoglutarate | aKG | Keto acid | 51 | 2-40 µmol/L | s, p, csf | A | ||||
Fumarate | Fum | Dicarboxylic acid | 444972 | 0.5-4 µmol/L | s, p, csf | A | ||||
Malate | Mal | β-Hydroxy acid | 525 | 2-21 µmol/L | s, p, csf | A | ||||
Pyruvate | Pyr | α-Keto acid | 1060 | 80-160 µmol/L | s, p, csf | A | ||||
Lactate | Lac | α-Hydroxy acid | 612 | 500-1600 µmol/L | s, p, csf | A | ||||
Formate | Frm | Short-chain fatty acid | 284 | 8-100 µmol/L | s, p, csf | A | ||||
Acetate | Ace | Short-chain fatty acid | 175-176 | 80-300 µmol/L | s, p | A | ||||
Propionate | Pro | Short-chain fatty acid | 1042 | 1-13 µmol/L | s, p | A | ||||
Butyrate | But | Short-chain fatty acid | 264 | 1-30 µmol/L | s, p | A | ||||
Isobutyrate | iBut | Short-chain fatty acid | 6590 | 0.7-6 µmol/L | s, p, csf | A | ||||
Valerate | Vlr | Short-chain fatty acid | 7991 | 0.2-1 µmol/L | s, p | A | ||||
Isovalerate | iVlr | Short-chain fatty acid | 10430 | 0.3-3 µmol/L | s, p | A | ||||
α-Methylbutyrate | aMB | Short-chain fatty acid | 8314 | 0.3-3 µmol/L | s, p | A | ||||
Methylmalonic acid | MMA | Carboxylic acid | 487 | <0.26 µmol/L | 0.03 | 2.4 | 3 | 0.81 | s, p, u | B |
Total homocysteine | tHcy | Sulfur amino acid | 91552 | 5-15 µmol/L | 0.1 | 1.4 | 2.7 | 0.72 | s, p, u | B |
Total cysteine | tCys | Sulfur amino acid | 5862 | 150-350 µmol/L | 50 | 1 | 2 | 0.62 | s, p, u | B |
Methionine | Met | Essential amino acid | 6137 | 18-50 µmol/L | 1 | 2.2 | 4.1 | 0.33 | s, p, u | B |
Serine | Ser | Polar amino acid | 5951 | 95-125 µmol/L | 5 | 1.3 | 1.7 | 0.71 | s, p, u | B |
Glycine | Gly | Hydrophobic amino acid | 750 | 200-300 µmol/L | 3 | 1.3 | 1.7 | 0.81 | s, p, u | B |
Cystathionine | Cysta | Thioether | 439258 | <0.4 µmol/L | 0.02 | 2.3 | 2.9 | 0.63 | s, p, u | B |
Sarcosine | Sarc | Methylated amino acid | 1088 | 0.7-2.3 µmol/L | 0.035 | 1.3 | 1.6 | 0.68 | s, p, u | B |
Histidine | His | Essential amino acid | 6274 | 50-100 µmol/L | 1 | 2 | 3 | na | s, p, u | B |
Tryptophan | Trp | Essential aromatic amino acid | 6305 | 40-90 µmol/L | 0.1 | 1.6 | 2.6 | 0.51 | s, p, u | B |
Kynurenine | Kyn | Trp metabolite | 161166 | 1.0-3.0 µmol/L | 0.12 | 1.9 | 2.3 | 0.68 | s, p, u | B |
Ornithine | Orn | Charged amino acid | 6262 | 30-90 µmol/L | 1 | 2.2 | 2.7 | s, p, u | B | |
Aspartic acid | Asp | Charged amino acid | 5960 | 0-26 µmol/L | 0.5 | 1.8 | 4 | s, p, u | B | |
Glutamic acid | Glu | Charged amino acid | 33032 | 20-140 µmol/L | 0.5 | 1.7 | 2.7 | s, p, u | B | |
Lysine | Lys | Essential amino acid | 5962 | 120-290 µmol/L | 1.2 | 1.4 | 1.9 | s, p, u | B | |
Alanine | Ala | Hydrophobic amino acid | 5950 | 230-510 µmol/L | 1 | 1.2 | 1.4 | s, p, u | B | |
Phenylalanine | Phe | Essential aromatic amino acid | 6140 | 26-85 µmol/L | 0.5 | 1.5 | 3 | s, p, u | B | |
Isoleucine | Ile | Essential BCAA | 6306 | 40-140 µmol/L | 0.5 | 1.5 | 1.8 | s, p, u | B | |
Leucine | Leu | Essential BCAA | 6106 | 70-170 µmol/L | 0.5 | 3.4 | 4 | s, p, u | B | |
Proline | Pro | Hydrophobic amino acid | 145742 | 110-360 µmol/L | 0.5 | 2.8 | 3.7 | s, p, u | B | |
Valine | Val | Essential BCAA | 6287 | 150-350 µmol/L | 0.5 | 2.2 | 2.7 | s, p, u | B | |
Asparagine | Asn | Polar amino acid | 6267 | 20-130 µmol/L | 0.6 | 3 | 3 | s, p, u | B | |
Glutamine | Gln | Polar amino acid | 5961 | 390-700 µmol/L | 10 | 2.1 | 2.7 | s, p, u | B | |
Threonine | Thr | Essential amino acid | 6288 | 70-240 µmol/L | 1.2 | 2.4 | 3.3 | s, p, u | B | |
Tyrosine | Tyr | Aromatic amino acid | 6057 | 40-110 µmol/L | 0.5 | 2.1 | 2.8 | s, p, u | B | |
α-Hydroxyglutaric acid | aHG | Alfa hydroxy acid | 43 | 0.15-2 µmol/L | s, p, u | B | ||||
3-Hydroxyisobutyrate | 3HIB | Val metabolite | 440873 | 15-25 µmol/L | 3 | 2.4 | 2.9 | s, p, u | B | |
2-Hydroxybutyrate | aHB | Alfa hydroxy acid | 11266 | 10-60 µmol/L | 3 | 1.7 | 2.3 | s, p | B | |
3-Hydroxybutyrate | bHB | Keton body | 441 | 20-700 µmol/L | 3 | 1.9 | 3.4 | s, p | B | |
Acetoacetate | AcAc | Keton body | 96 | 10-200 µmol/L | 5 | s, p | B | |||
Carboxymethyllysine | CML | an AGE | 123800 | 0.05-0.3 µmol/L | 0.03 | s, p | B | |||
Carboxyethyllysine | CEL | an AGE | 23400779 | 0.05-0.4 µmol/L | 0.03 | s, p | B | |||
2-Aminoadipic acid | 2AAA | Lys metabolite | 469 | 0.3-1.8 µmol/L | s, p | B | ||||
β-Aminoisobutyrate | BAIBA | Val metabolite | 64956 | 0.3-2.0 µmol/L | s, p | B | ||||
Beta-alanine | bAla | Beta amino acid | 239 | 0.5-10 µmol/L | s, p | B | ||||
3-Hydroxykynurenine | HK | 11811 | u | B | ||||||
Kynurenic acid | KA | 3845 | u | B | ||||||
Anthranilic acid | AA | 227 | u | B | ||||||
Xanthurenic acid | XA | 5699 | u | B | ||||||
3-Hydroxyanthranilic acid | HAA | 86 | u | B | ||||||
Formiminoglutamic acid | Figlu | 439233 | u | B | ||||||
Choline | Chol | Quarternary ammonium | 305 | 5-15 µmol/L | 0.5 | 2.8 | 3.2 | 0.36 | s, p, u | C |
Choline, total | tChol | Choline esters | 2-3 mmol/L | 0.5 | s, p | C | ||||
Trimethylamine N-oxide | TMAO | Amine oxide | 1145 | 0.5-60 µmol/L | 0.1 | 4 | 4.1 | <0.38 | s, p, u | C |
Betaine | Bet | Methylated amino acid | 247 | 20-60 µmol/L | 0.5 | 3.8 | 4.5 | 0.65 | s, p, u | C |
Dimethylglycine | DMG | Methylated amino acid | 673 | 1.5–5 µmol/L | 0.25 | 5.5 | 5.9 | 0.64 | s, p, u | C |
Total homocysteine | tHcy | Amino acid | 91552 | 6-20 µmol/L | 0.1 | 1 | 2 | 0.72 | s, p, u | C |
Creatine | Crn | Alpha amino acid | 586 | 10-100 µmol/L | 1 | 3.9 | 4 | na | s, p, u | C |
Creatinine | Creat | Alpha amino acid | 588 | 50-100 µmol/L | 0.25 | 2.6 | 3.1 | 0.79 | s, p, u | C |
Methionine | Met | Essential amino acid | 6137 | 18-50 µmol/L | 1 | 4.1 | 4.5 | 0.33 | s, p | C |
Methionine sulfoxide | MetSo | Polar amino acid | 158980 | 0.5-5 µmol/L | 0.06 | 7.1 | 7.9 | 0.36 | s, p | C |
Cystathionine | Cysta | Thioether | 439258 | < 0.4 µmol/L | 0.025 | 6-12 | 7-10 | 0.63 | s, p | C |
Total cysteine | tCys | Sulfur amino acid | 5862 | 150-400 µmol/L | 0.1 | 2 | 6 | 0.56 | s, p | C |
Histidine | His | Essential amino acid | 6274 | 50-100 µmol/L | 0.25 | 3.5 | 3.8 | na | s, p | C |
3-Methylhistidine | 3-MH | Amino acid | 92105 | 2.7-10 µmol/L | 0.6 | 4.4 | 4.9 | na | s, p, u | C |
1-Methylhistidine | 1-MH | Amino acid | 64969 | 0.5-15 µmol/L | 0.25 | 3.7 | 3.9 | na | s, p, u | C |
Citrulline | Ctn | Amino acid | 9750 | 10-60 µmol/L | 4 | 7-8 | 6-9 | na | s, p | C |
Ornithine | Orn | Charged amino acid | 6262 | 30-90 µmol/L | 0.5 | 7-8 | 7-9 | na | s, p | C |
Arginine | Arg | Charged amino acid | 6322 | 40-100 µmol/L | 0.25 | 2.6 | 3 | 0.53 | s, p | C |
Asymmetric dimethylarginine | ADMA | Guanidinated amino acid | 123831 | 0.4-0.8 µmol/L | 0.08 | 5.2 | 5.5 | 0.53 | s, p | C |
Symmetric dimethylarginine | SDMA | Guanidinated amino acid | 169148 | 0.4-0.9 µmol/L | 0.08 | 4.8 | 5.2 | 0.62 | s, p | C |
Homoarginine | hArg | Guanidinated amino acid | 9085 | 1-6 µmol/L | 0.1 | 5.8 | 6 | 0.65 | s, p | C |
Trimethyllysine | TML | Methylated amino acid | 440121 | 0.3-2 µmol/L | 0.2 | 4 | 4.4 | 0.15 | s, p | C |
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 µmol/L | 0.2 | s, p | C | |||
Carnitine | C0 | Carnitine | 288 | 20-80 µmol/L | 0.5 | 0.69 | s, p | C | ||
Carnitine, total | tC0 | Carnitines | 30-90 µmol/L | 0.5 | s, p | C | ||||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 µmol/L | 0.1 | 0.63 | s, p | C | ||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 µmol/L | 0.05 | 0.62 | s, p | C | ||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 µmol/L | 0.012 | s, p | C | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 µmol/L | 0.05 | 0.68 | s, p | C | ||
Glutarylcarnitine | C5DC | Acylcarnitine | 71464488 | < 0.05 µmol/L | 0.01 | s, p | C | |||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 µmol/L | 0.01 | s, p | C | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 µmol/L | 0.05 | 0.41 | s, p | C | ||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 µmol/L | 0.02 | s, p | C | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 µmol/L | 0.02 | s, p | C | |||
Pyridoxal 5′-phosphate | PLP | B6 vitamer | 1051 | 15–150 nmol//L | 0.2 | 3.5 | 5.7 | 0.7 | s, p | D |
7-70 nmol | csf | D | ||||||||
Pyridoxal | PL | B6 vitamer | 1050 | 5–150 nmol/L | 0.2 | 3.5 | 5.1 | 0.62 | s, p | D |
10-50 nmol/L | csf | D | ||||||||
4-Pyridoxic acid | PA | B6 vitamer | 6723 | 10–200 nmol/L | 0.5 | 3.6 | 5.8 | 0.58 | s, p | D |
0-15 nmol/L | csf | D | ||||||||
Pyridoxine | PN | B6 vitamer | 1054 | 0.05 | 4.5 | 5.2 | na | s, p | D | |
Thiamine | Thi | B1 vitamer | 1130 | 2–50 nmol/L | 0.25 | 3.5 | 4.9 | s, p | D | |
5-40 nmol/L | csf | D | ||||||||
Thiamine monophosphate | TMP | B1 vitamer | 1131 | 2–15 nmol/L | 0.5 | 7.1 | 11.6 | s, p | D | |
25-75 µmol/L | csf | D | ||||||||
Riboflavin | Ribo | B2 vitamer | 493570 | 5–100 nmol/L | 0.2 | 6 | 7.1 | 0.79 | s, p | D |
5-25 nmol/L | csf | D | ||||||||
Flavin mononucleotide | FMN | B2 vitamer | 643976 | 3–30 nmol/L | 0.4 | 5.7 | 8.1 | 0.69 | s, p | D |
1-2 nmol/L | csf | D | ||||||||
Cystathionine | Cysta | Thioether | 439258 | <0.4 µmol/L | 0.02 | 3.4 | 4.5 | 0.63 | s, p | D |
Neopterin | Neopt | Pteridine | 4455 | 5-50 nmol/L | 0.7 | 5.3 | 6.6 | 0.6 | s, p | D |
5-50 nmol/L | csf | D | ||||||||
Tryptophan | Trp | Essential aromatic amino acid | 6305 | 40-90 µmol/L | 4 | 3.1 | 3.9 | 0.51 | s, p | D |
2-7 µmol/L | csf | D | ||||||||
Kynurenine | Kyn | Trp metabolite | 161166 | 1.0-3.0 µmol/L | 0.007 | 3.6 | 5.1 | 0.68 | s, p | D |
0.02-0.12 µmol/L | csf | D | ||||||||
Kynurenic acid | KA | Trp metabolite | 3845 | 20-100 nmol/L | 0.4 | 4.4 | 5.4 | 0.68 | s, p | D |
0.5-15 nmol/L | csf | D | ||||||||
Quinaldic acid | Qld | Trp (KA) metabolite | 7124 | 0.2-100 nmol/L | 0.5 | 6-7 | 6-8 | na | s, p | D |
0.1-10 nmol/L | csf | D | ||||||||
Anthranilic acid | AA | Trp metabolite | 227 | 7-30 nmol/L | 0.7 | 7.4 | 9.5 | 0.64 | s, p | D |
3-14 nmol/L | csf | D | ||||||||
3-Hydroxykynurenine | HK | Trp metabolite | 11811 | 25-80 nmol/L | 2 | 3.2 | 4.5 | 0.62 | s, p | D |
0.1-25 nmol/L | csf | D | ||||||||
Xanthurenic acid | XA | Trp metabolite | 5699 | 2-35 nmol/L | 0.5 | 4.8 | 5.7 | 0.58 | s, p | D |
<0.5 nmol/L | csf | D | ||||||||
3-Hydroxyanthranilic acid | HAA | Trp metabolite | 86 | 10-80 nmol/L | 2 | 4.6 | 6 | 0.54 | s, p | D |
0-7 nmol/L | csf | D | ||||||||
Cinnabarinic acid | CBA | Trp (HAA) metabolite | 114918 | 0.5 | na | s, p | D | |||
csf | D | |||||||||
Picolinic acid | Pic | Trp metabolite | 1018 | 20-100 nmol/L | 8 | 6-7 | 5-8 | na | s, p | D |
5-100 nmol/L | csf | D | ||||||||
Quinolinic acid | QA | Trp metabolite | 1066 | 150-700 nmol/L | 1.6 | 7-8 | 7-10 | na | s, p | D |
10-150 nmol/L | csf | D | ||||||||
Nicotinic acid | NA | B3 vitamer | 938 | <20 nmol/L | 10 | 4 | 5.4 | na | s, p | D |
Nicotinamide | NAM | B3 vitamer | 936 | 100-600 nmol/L | 20 | 4.2 | 6.1 | na | s, p | D |
5-200 nmol/L | csf | D | ||||||||
N1-methylnicotinamide | mNAM | B3 vitamer | 457 | 20-250 nmol/L | 5 | 4 | 5.5 | na | s, p | D |
5-100 nmol/L | csf | D | ||||||||
Cotinine | Cot | Nicotine metabolite | 854019 | <3000 nmol/L | 1 | 3 | 4.2 | 0.92 | s, p, u | D |
Trans-3′-hydroxycotinine | OHCot | Nicotine metabolite | 107963 | <1500 nmol/L | 2 | 3.6 | 4.5 | 0.85 | s, p, u | D |
Trigonelline | Trig | Alkaloid | 5570 | <25 µmol/L | 0.01 | 2.9 | 3.8 | 0.66 | s, p | D |
Trimethylamine N-oxide | TMAO | Amine oxide | 1145 | 0.5-60 µmol/L | 4.2 | 6.9 | <0.38 | s, p, u | D | |
0.2-12 µmol/L | csf | D | ||||||||
Imidazole propionate | ImP | Histidine metabolite | 70630 | 3-500 nmol/L | 2 | s, p | D | |||
Urocanate | Uro | Histidine metabolite | 0.1-0.6 µmol/L | s, p | D | |||||
3-Indoxyl sulfate | 3IS | Indole, Trp metabolite | 10258 | 0.9-30 µmol/L | 0.1 | s, p | D | |||
Indole-3-acetamide | IAM | Indole, Trp metabolite | 397 | 0-10 nmol/L | 0.8 | s, p | D | |||
Indole-3-acetate | IAA | Indole, Trp metabolite | 802 | 0.3-23 µmol/L | 0.05 | s, p | D | |||
Indole-3-acetaldehyde | IAAld | Indole, Trp metabolite | 800 | s, p | D | |||||
Indole-3-aldehyde | IAld | Indole, Trp metabolite | 10256 | 0.01-0.20 µmol/L | 4 | s, p | D | |||
Indole-3-lactate | ILA | Indole, Trp metabolite | 92904 | 0.08-5 µmol/L | 0.025 | s, p | D | |||
Indole-3-acrylate | IAcA | Indole, Trp metabolite | 5375048 | s, p | D | |||||
Indole-3-propionate | IPA | Indole, Trp metabolite | 3744 | 0.5-12 µmol/L | 0.02 | s, p | D | |||
5-Methyl-tetrahydrofolate | mTHF | Folate | 439234 | >7.5 nmol/L | 0.07 | 5-9 | 4-5 | na | s, p | E |
5-Formyl-tetrahydrofolate | fTHF | Folate | 6006 | 0-2 nmol/l | 0.52 | 8-9 | 6-11 | na | s, p | E |
Folic acid | FA | Folate | 6037 | 0-2 nmol/L | 0.27 | 7-8 | 6-12 | na | s, p | E |
4-Alfa-hydroxy-5-methyl-THF | hmTHF | Oxidized folate | 0.2 | 6-10 | 6-7 | na | s, p | E | ||
Para-aminobenzoylglutamate | pABG | Folate catabolite | 196473 | 0-0.5 nmol/L | 0.08 | 6-9 | 3-10 | na | s, p | E |
Acetamidobenzoylglutamate | apABG | Folate catabolite | 3080868 | 0.1-1 nmol/L | 0.13 | 5-6 | 5-10 | na | s, p | E |
Serum folate as pABG equivalents | S pABG | Folate | >7.5 nmol/L | s, p | E | |||||
RBC folate as pABG equivalents | E pABG | Folate | >340 nmol/L | e | E | |||||
Serum folate | s-Folate | B-vitamin | >7.5 nmol/L | 2 | 4 | 5 | 0.56 | s, p | F | |
Erythrocyte folate | e-Folate | B-vitamin | >340 nmol/L | e | F | |||||
Serum cobalamin | s-B12 | B-vitamin | >150 pmol/L | 30 | 4 | 5 | 0.82 | s, p | F | |
C-reactive protein | hsCRP | Protein | 0-10 µg/ml | 0.06 | 3-6 | 3-7 | 0.54 | s, p | G | |
Serum amyloid A and variants | SAA | Protein | 0-20 µg/ml | 0.04 | na | s, p | G | |||
Calprotectin and variants | Calp | Protein | 0-30 µg/ml | 0.02 | na | s, p | G | |||
Cystatin C and variants | Cys-C | Protein | 0-8 µg/ml | 0.01 | 3-9 | 5-8 | na | s, p | G | |
HbA1c | HbA1c | Protein | 4-14 % | na | 5 | na | na | w | G | |
All-trans retinol | Vit. A | A vitamer | 445354 | 1.46-2.84 µmol/L | 0.1 | 2.9 | 3.6 | 0.87 | s, p | H |
25-hydroxy vitamin D2 | 25OH-D2 | D vitamer | 5710148 | 0-30 nmol/L | 3.3 | 6.6 | 8.1 | na | s, p | H |
25-hydroxy vitamin D3 | 25OH-D3 | D vitamer | 5283731 | 32.4-98.5 nmol/L | 3.3 | 5.1 | 6.1 | 0.71 | s, p | H |
alpha-tocopherol | aToc | E vitamer | 14985 | 18.9-38.8.0 µmol/L | 2 | 4.3 | 5.8 | 0.86 | s, p | H |
gamma-tocopherol | gToc | E vitamer | 92729 | 2-11 µmol/L | 0.1 | 3.7 | 5 | na | s, p | H |
Phylloquinone | Vit. K1 | K vitamer | 5284607 | 0.1-8.7 nmol/L | 0.5 | 4.8 | 7.4 | 0.49 | s, p | H |
Menaquinone-4 | Vit. K2 | K vitamer | 5282367 | na | na | na | na | H | ||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 µmol/L | na | na | na | 0.38 | s, p | H |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 µmol/L | na | na | na | 0.49 | s, p | H |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 µmol/L | na | na | na | 0.40 | s, p | H |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 µmol/L | na | na | na | s, p | H | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 µmol/L | na | na | na | s, p | H | |
Trimethyllysine | TML | Methylated amino acid | 0.3-2 µmol/L | s, p | I | |||||
Butyrobetaine | BB | Quarternary ammonium | 725 | 0.4-2 µmol/L | 0.2 | s, p | I | |||
Carnitine | C0 | Carnitine | 288 | 20-80 µmol/L | 0.5 | s, p | I | |||
Carnitine, total** | tC0 | Carnitines | 30-90 µmol/L | 0.5 | s, p | I | ||||
Acetylcarnitine | C2 | Acylcarnitine | 7045767 | 3-15 µmol/L | 0.1 | s, p | I | |||
Propionylcarnitine | C3 | Acylcarnitine | 107738 | 0.2-1.5 µmol/L | 0.05 | s, p | I | |||
Malonylcarnitine | C3DC | Acylcarnitine | 91825606 | 0.03-0.2 µmol/L | s, p | I | ||||
Butyrylcarnitine | C4 | Acylcarnitine | 213144 | 0.1-0.5 µmol/L | 0.012 | s, p | I | |||
Isovalerylcarnitine | iC5 | Acylcarnitine | 6426851 | 0.06-0.2 µmol/L | 0.05 | s, p | I | |||
Glutarylcarnitine | C5DC | Acylcarnitine | 71464488 | < 0.05 µmol/L | 0.01 | s, p | I | |||
Hexanoylcarnitine | C6 | Acylcarnitine | 6426853 | 0.01-1.2 µmol/L | 0.01 | s, p | I | |||
Octanoylcarnitine | C8 | Acylcarnitine | 123701 | 0.06-0.3 µmol/L | 0.05 | s, p | I | |||
Decanoylcarnitine | C10 | Acylcarnitine | 10245190 | 0.2-1 µmol/L | 0.02 | s, p | I | |||
Dodecanoylcarnitine | C12 | Acylcarnitine | 168381 | < 0.4 µmol/L | 0.02 | s, p | I | |||
Myristoylcarnitine | C14 | Acylcarnitine | 6426854 | 0.01-0.1 µmol/L | na | na | na | s, p | I | |
Palmitoylcarnitine | C16 | Acylcarnitine | 461 | 0.05-0.25 µmol/L | na | na | na | s, p | I | |
Stearoylcarnitine | C18 | Acylcarnitine | 52922056 | 0.03-0.1 µmol/L | na | na | na | s, p | I | |
Oleoylcarnitine | C18:1 | Acylcarnitine | 46907933 | 0.04-0.2 µmol/L | na | na | na | s, p | I | |
Linoleylcarnitine | C18:2 | Acylcarnitine | 6450015 | 0.01-0.1 µmol/L | na | na | na | s, p | I |