BEVITAL AS

Stability curves

This page provides data on the stability during storage and freezing/thawing of most biomarkers or metabolites included in the repertoire of BEVITAL by April 2019.

BEVITAL platforms A – H

E: LC-MS/MS

Folate species and catabolites.

F: Microbiological assay

Folate (B9) and cobalamin (B12).

H: LC-MS/MS

Lipid-soluble vitamins and long-chain acylcarnitines.
Amino- and carboxylic acids.

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

For two pairs of metabolites (asparagine / aspartic acid; glutamine / glutamic acid) characterized by interconversion, the right panel shows the concentration of the two metabolites combined. Thus, summarizing the concentrations of such source-product pairs is a useful strategy to correct for preanalytical instability.

Choline derivatives. Charged, methylated or sulfur amino acids. Short- and medium-chain acylcarnitines.

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

Kynurenine pathway and B vitamins (B1, B2, B3, B6).

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

For two pairs of metabolites (thiamine monophosphate (TMP) / thiamine; flavin mononucleotide (FMN) / riboflavin) characterized by interconversion, the right panel shows the concentration of the two metabolites combined. Thus, summarizing the concentrations of such source-product pairs is a useful strategy to correct for preanalytical instability.

Folate species and catabolites.

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

For one pair of metabolites (5-methyl-tetrahydrofolate / 4-alfa-hydroxy-5-methyl-THF) characterized by interconversion, the right panel shows the concentration of the two metabolites combined. Thus, summarizing the concentrations of such source-product pairs is a useful strategy to correct for preanalytical instability.

Folate (B9) and cobalamin (B12).

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

Protein biomarkers

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

Lipid-soluble vitamins and long-chain acylcarnitines.

The panels (click on biomarkers above) show the stability of all biomarkers in EDTA plasma and serum at room temperature (left) for the indicated duration and after increasing number of freeze-thaw cycles (right). The white zone indicates +/- 15% deviation from the average of the first three time points for plasma. Data are given as geometric mean with standard error (SE) for samples from 15 healthy subjects.

September 6, 2022

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