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Biomarker overview

Bevital´s targeted metabolomics analysis currently includes 145 biomarkers. All biomarkers are listed below in alphabetical order and can be sorted by category and analytical platform.

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Biomarker – platform organization
Biomarker – platform organization

Click on biomarker or platform below for detailed information.

Last update: October 22, 2024
BiomarkerAbbrClassCategoryPanelAnalytical platform
1-Methylhistidine1-MHAmino acidMeat & fish intakeNutritionC
2-Aminoadipic acid2AAALys metaboliteAmino acid catabolitesCardiometabolicB
2-HydroxybutyrateaHBAlfa hydroxy acidAmino acid catabolitesCardiometabolicB
3-Hydroxyanthranilic acidHAATrp metaboliteKynureninesInflammationD
3-HydroxybutyratebHBKetone bodyAmino acid catabolitesCardiometabolicB
3-Hydroxyisobutyrate3HIBVal metaboliteAmino acid catabolitesCardiometabolicB
3-HydroxykynurenineHKTrp metaboliteKynureninesInflammationD
3-Indoxyl sulfate3ISIndole, Trp metaboliteIndolesMicrobiomeD
3-Methylhistidine3-MHAmino acidMeat & fish intakeNutritionC
4-Alpha-hydroxy-5-methyl-THFhmTHFOxidized folateB-vitamins, functional markers, and methyl donorsE
4-Pyridoxic acidPAB6 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
5-Formyl-tetrahydrofolatefTHFFolateB-vitamins, functional markers, and methyl donorsE
5-Methyl-tetrahydrofolatemTHFFolateB-vitamins, functional markers, and methyl donorsE
25-hydroxy vitamin D225OH-D2D vitamerFat-soluble vitaminsNutritionH
25-hydroxy vitamin D325OH-D3D vitamerFat-soluble vitaminsNutritionH
AcetamidobenzoylglutamateapABGFolate cataboliteB-vitamins, functional markers, and methyl donorsE
AcetateAceShort-chain fatty acidSCFAsMicrobiomeA
AcetoacetateAcAcKetone bodyKetone bodiesCardiometabolicB
AcetylcarnitineC2AcylcarnitineAcylcarnitiesCardiometabolicI
AlanineAlaHydrophobic amino acidAmino acidsCardiometabolicB
All-trans retinolVit. AA vitamerFat-soluble vitaminsNutritionH
Alpha-tocopherolaTocE vitamerFat-soluble vitaminsNutritionH
Anthranilic acidAATrp metaboliteKynureninesInflammationD
ArginineArgCharged amino acidAmino acidsCardiometabolicC
AsparagineAsnPolar amino acidAmino acidsCardiometabolicB
Aspartic acidAspCharged amino acidAmino acidsCardiometabolicB
Asymmetric dimethylarginineADMAGuanidinated amino acidC
BetaineBetMethylated amino acidCholine metabolitesMicrobiomeC
ButyrateButShort-chain fatty acidSCFAsMicrobiomeA
ButyrobetaineBBQuarternary ammoniumAcylcarnitiesCardiometabolicI
ButyrylcarnitineC4AcylcarnitineAcylcarnitiesCardiometabolicI
C-reactive proteinCRPProteinProteinInflammationG
Calprotectin and variantsS100AProteinProteinInflammationG
CarboxyethyllysineCELAGEAGEsCardiometabolicB
CarboxymethyllysineCMLAGEAGEsCardiometabolicB
CarnitineC0CarnitinesAcylcarnitiesCardiometabolicC, I
Carnitine, totaltC0CarnitinesAcylcarnitiesCardiometabolicC
CholineCholQuarternary ammoniumCholine metabolitesMicrobiomeC
CitrateCitTricarboxylic acidTCA metabolitesCardiometabolicB
CitrullineCtnAmino acidC
CotinineCotNicotine metaboliteTobacco use and coffee intakeNutritionD
CreatineCrnAlpha amino acidMeat and fish intakeNutritionC
CreatinineCreatAlpha amino acidMeat and fish intakeNutritionC
CystathionineCystaThioetherB, D
Cystatin C and variantsCnCProteinProteinG
DecanoylcarnitineC10AcylcarnitineAcylcarnitiesCardiometabolicI
DimethylglycineDMGMethylated amino acidCholine metabolitesMicrobiomeC
DodecanoylcarnitineC12AcylcarnitineAcylcarnitiesCardiometabolicI
Erythrocyte folatee-FolateB-vitaminB-vitamins, functional markers, and methyl donorsF
Flavin mononucleotideFMNB2 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
Folic acidFAFolateB-vitamins, functional markers, and methyl donorsE
FormateFrmShort-chain fatty acidSCFAsMicrobiomeA
FumarateFumDicarboxylic acidTCA metabolitesCardiometabolicB
Gamma-tocopherolgTocE vitamerFat-soluble vitaminsNutritionH
Glutamic acidGluCharged amino acidAmino acidsCardiometabolicB
GlutamineGlnPolar amino acidAmino acidsCardiometabolicB
GlutarylcarnitineC5DCAcylcarnitineAcylcarnitiesCardiometabolicC
GlycineGlyHydrophobic amino acidAmino acidsCardiometabolicB
HbA1cHbA1cProteinProteinG
HexadecanoylcarnitineC16-OHAcylcarnitineAcylcarnitiesCardiometabolicI
HexanoylcarnitineC6AcylcarnitineAcylcarnitiesCardiometabolicI
HistidineHisEssential amino acidAmino acidsCardiometabolic, NutritionB, C
Hydroxybutyrylcarnitine C4-OHAcylcarnitineAcylcarnitiesCardiometabolicI
Hydroxyoctadecanoylcarnitine C18-OHAcylcarnitineAcylcarnitiesCardiometabolicI
Hydroxytetradecanoylcarnitine C14-OHAcylcarnitineAcylcarnitiesCardiometabolicI
Imidazole propionateImPHis metaboliteIndolesMicrobiomeD
Indole-3-acetaldehydeIAAldIndole, Trp metaboliteIndolesMicrobiomeD
Indole-3-acetamideIAMIndole, Trp metaboliteIndolesMicrobiomeD
Indole-3-acetateIAAIndole, Trp metaboliteIndolesMicrobiomeD
Indole-3-lactateILAIndole, Trp metaboliteIndolesMicrobiomeD
Indole-3-propionateIPAIndole, Trp metaboliteIndolesMicrobiomeD
IsobutyrateiButShort-chain fatty acidSCFAsMicrobiomeA
IsocitrateiCitTricarboxylic acidTCA metabolitesCardiometabolicB
IsoleucineIleEssential BCAAAmino acidsCardiometabolic, NutritionB
IsovalerateiVlrShort-chain fatty acidSCFAsMicrobiomeA
IsovalerylcarnitineiC5AcylcarnitineAcylcarnitiesCardiometabolicI
Kynurenic acidKATrp metaboliteKynureninesInflammationD
KynurenineKynTrp metaboliteKynureninesInflammationB, D
LactateLacα-Hydroxy acidTCA metabolitesCardiometabolicB
LeucineLeuEssential BCAAAmino acidsCardiometabolic, NutritionB
LinoleylcarnitineC18:2AcylcarnitineAcylcarnitiesCardiometabolicH, I
LysineLysEssential charged amino acidAmino acidsCardiometabolic, NutritionB
MalateMalβ-Hydroxy acidTCA metabolitesCardiometabolicB
MalonylcarnitineC3-DCAcylcarnitineAcylcarnitiesCardiometabolicI
Menaquinone-4Vit. K2K vitamerFat-soluble vitaminsNutritionH
MethionineMetEssential amino acidAmino acidsCardiometabolic, NutritionB, C
Methionine sulfoxideMetSoPolar amino acidC
Methylmalonic acidMMACarboxylic acidB-vitamins, functional markers, and methyl donorsNutritionB
MyristoylcarnitineC14AcylcarnitineAcylcarnitiesCardiometabolicH, I
N1-methylnicotinamidemNAMB3 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
NeopterinNeoptPteridineInflammationD
NicotinamideNAMB3 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
Nicotinic acid NAB3 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
OctanoylcarnitineC8AcylcarnitineAcylcarnitiesCardiometabolicI
OleoylcarnitineC18:1AcylcarnitineAcylcarnitiesCardiometabolicI
OrnithineOrnCharged amino acidAmino acidsCardiometabolicB
PalmitoylcarnitineC16AcylcarnitineAcylcarnitiesCardiometabolicI
Para-aminobenzoylglutamatepABGFolate cataboliteB-vitamins, functional markers, and methyl donorsE
PhenylacetylglutaminePAGlnn-acyl-alpha amino acidAmino acidsCardiometabolicB
PhenylalaninePheEssential aromatic amino acidAmino acidsCardiometabolic, NutritionB
PhylloquinoneVit. K1K vitamerFat-soluble vitaminsNutritionH
Picolinic acid PicTrp metaboliteKynureninesInflammationD
ProlineProHydrophobic amino acidAmino acidsCardiometabolicB
PropionatePropShort-chain fatty acidSCFAsMicrobiomeA
PropionylcarnitineC3AcylcarnitineAcylcarnitiesCardiometabolicI
PyridoxalPLB6 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
Pyridoxal 5-phosphatePLPB6 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
PyridoxinePNB6 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
PyruvatePyrα-Keto acidTCA metabolitesCardiometabolicB
Quinaldic acid QldTrp metaboliteKynureninesInflammationD
Quinolinic acid QATrp metaboliteKynureninesInflammationD
RBC folate as pABG equivalentsE pABGFolateB-vitamins, functional markers, and methyl donorsE
RiboflavinRiboB2 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
SarcosineSarcMethylated amino acidAmino acidsCardiometabolicB
SerineSerPolar amino acidAmino acidsCardiometabolicB
Serum amyloid A and variantsSAAProteinProteinInflammationG
Serum cobalamins-B12B-vitaminB-vitamins, functional markers, and methyl donorsNutritionF
Serum folates-FolateB-vitaminB-vitamins, functional markers, and methyl donorsNutritionF
Serum folate as pABG equivalentsS pABGFolateB-vitamins, functional markers, and methyl donorsE
StearoylcarnitineC18AcylcarnitineAcylcarnitiesCardiometabolicI
SuccinateSucDicarboxylic acidD (under development)
Succinylcarnitine C4-DCAcylcarnitineAcylcarnitiesCardiometabolicI
Symmetric dimethylarginineSDMAGuanidinated amino acidC
ThiamineThiB1 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
Thiamine monophosphateTMPB1 vitamerB-vitamins, functional markers, and methyl donorsNutritionD
ThreonineThrEssential amino acidAmino acidsCardiometabolic, NutritionB
TiglylcarnitineC5:1AcylcarnitineAcylcarnitiesCardiometabolicI
Total cholinetCholCholine estersC
Total cysteinetCysSulfur amino acidAmino acidsCardiometabolicB, C
Total homocysteinetHcySulfur amino acidB-vitamins, functional markers, and methyl donorsNutritionB, C
Trans-3′-hydroxycotinineOHCotNicotine metaboliteTobacco use and coffee intakeNutritionD
TrigonellineTrigAlkaloidTobacco use and coffee intakeNutritionD
Trimethylamine N-oxideTMAOAmine oxideMeat and fish intakeNutritionC, D
TrimethyllysineTMLMethylated amino acidC
TryptophanTrpEssential aromatic amino acidAmino acidsCardiometabolic, NutritionB, D
TyrosineTyrAromatic amino acidAmino acidsCardiometabolicB
ValerateVlrShort-chain fatty acidSCFAsMicrobiomeA
ValineValEssential BCAAAmino acidsCardiometabolic, NutritionB
Xanthurenic acidXATrp metaboliteKynureninesInflammationD
α-Hydroxyglutaric acidaHGAlpha hydroxy acidAmino acid catabolitesCardiometabolicB
α-Ketoglutaric acidaKGKeto acidTCA metabolitesCardiometabolicB
α-MethylbutyrateaMBShort-chain fatty acidSCFAsMicrobiomeA
β-AlaninebAlaBeta amino acidAmino acidsCardiometabolic, NutritionB
β-AminoisobutyrateBAIBAVal metaboliteAmino acid catabolitesCardiometabolicB
β-Hydroxy-β-methylbutyrateHMBLeu metaboliteAmino acid catabolitesCardiometabolicA
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Cardiometabolic
Inflammation
Microbiome
Nutrition
Categories

Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs



Kynurenines, ratio-derived metabolites, proteins





SCFAs, indoles, choline metabolites, amino acid derived





B-vitamins, functional markers, and methyl donors, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
Biomarkers (n)
65
19
20
41
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Amino acids: Alanine, Arginine, Asparagine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Histidine, Isoleucine, Kynurenine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Threonine, Total cysteine, Tryptophan, Tyrosine, Valine

Amino acid catabolites: 2-Aminoadipic acid, 2-Hydroxybutyrate, 3-Hydroxysiobutyrate, α-Hydroxyglutaric acid, β-Alanine, β-Aminoisobutyrate, β-Hydroxy B-methylbutyric acid, Phenylacetylglutamine

Acylcarnities: BB, C0, C2, C3, C3-DC, C4, C4-OH, C4-DC, iC5, C5-DC, C5:1, C6, C8, C10, C12, C14, C14-OH, C16, C16-OH, C18, C18-OH, C18:1, C18:2

TCA metabolites: α-Ketoglutarate, Citrate, Fumarate, Isocitrate, Lactate, Malate, Pyruvate

Ketone bodies: Acetoacetate, 3-Hydroxybutyrate

AGEs: Carboxyethyllysine, Carboxymethyllysine

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Kynurenines: 3-hydroxykynurenine, 3-hydroxyanthranilic acid, Anthranilic acid, Kynurenine, Kynurenic acid, Nicotinic acid, Nicotinamide, N1-methylnicotinamide, Picolinic acid, Quinaldic acid, Quinolinic acid, Xanthurenic acid

Neopterin

Proteins: C-Reactive protein, Calprotectin, Serum Amyloid A

Ratio-derived: Kynurenine/tryptophan ratio, PAr index (PLP, PL, PA)

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SCFAs: Acetate, Butyrate, Formate, Isobutyrate, Isovalerate, Propionate, Valerate, α-Methylbutyrate

Indoles: 3-Indoxyl sulfate, Imidazole propionate, Indole-3-acetamide, Indole-3-acetate, Indole-3-aldehyde, Indole-3-lactate, Indole-3-propionate

Choline metabolites: Choline, Betaine, DMG, TMAO

Amino acid derived: Phenylacetylglutamine

View

B-vitamins, functional markers, and methyl donors: 4-Pyridoxic acid, Betaine, Choline, Cobalamin, Flavin mononucleotide, Folate, Methylmalonic acid, N1-methylnicotinamide, Nicotinamide, Nicotinic acid, Pyridoxal, Pyridoxal 5-phosphate, Pyridoxine, Riboflavin, Thiamine, Thiamine monophosphate, Total homocysteine

Fat-soluble vitamins: 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, α-Tocopherol (Vit. E), All-trans retinol (Vit. A), Phylloquinone (Vit. K1), y-Tocopherol (Vit. E)

Essential amino acids: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

Meat and fish intake: 1-Methylhistidine, 3-Methylhistidine, B-Alanine, Creatine, Creatinine, TMAO

Tobacco use and coffee intake: Cotinine, Trans-3-hydroxycotinine, Trigonelline

Volume (μl)
200
150
250
300
Analytical techniques
GC- and LC-MS/MS
LC- and MALDI-MS
GC- and LC-MS/MS
GC- and LC-MS/MS

Turnaround time

2-6 weeks, depending on number of samples and laboratory capacity.
Please contact us for a projected time estimate specific to your project.

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Ulvik et al.