BEVITAL AS

Targeted Metabolomics Services

2-Hydroxy-butyrate

aHB
Updated 21/12/2022

What is measured?

Synonyms: α-Hydroxybutyrate, 2-hydroxybutyric acid
Method(s): GC-MS/MS (1).

What is 2-hydroxybutyrate?

2-Hydroxybutyrate (aHB) is an organic acid that is derived from α-ketobutyrate, which is generated during methionine and threonine catabolism or glutathione synthesis (cysteine formation). aHB is an early biomarker of insulin resistance and impaired glucose regulation (2) that appears to arise due to increased lipid oxidation and oxidative stress.

Indication(s)

Assessment of diabetes status and impaired glucose tolerance.

Specimen, collection and processing

Patient/subject: No special precaution.
Matrix: Serum or EDTA plasma.
Volume: Minimum volume is 50 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: Probably stable.

Transportation

Frozen, on dry ice. (for general instruction on transportation, click here)

Reported values, interpretation

Reported values: 10-60 µmol/L
Intraclass correlation coefficient (ICC): na.

Literature

1. Midttun, Ø., McCann, A., Aarseth, O., Krokeide, M., Kvalheim, G., Meyer, K., and Ueland, P.M. (2016). Combined measurement of 6 fat-soluble vitamins and 26 water-soluble functional vitamin markers and amino acids in 50 μL of serum or plasma by high-throughput mass spectrometry. Anal Chem 88, 10427-436.
2. Cobb, J., Eckhart, A., Motsinger-Reif, A., Carr, B., Groop, L., and Ferrannini, E. (2016). α-Hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance. Diabetes Care 39, 988-995.

Scroll to Top

Olink Proteomics

Please fill out the fields below (*required).
We will respond to you ASAP.
Thank you!

Customized analyses

Please fill out the fields below (*required).
We will reply to you soon for a detailed project discussion.
Thank you for reaching out to Bevital!

Mix-and-Match

Please fill out the fields below (*required).
We will respond to you as soon as possible.
Thank you for reaching out to Bevital!

Ready-to-Run

Please fill out the fields below (*required).
We will respond ASAP.
Thank you!

Thanks for joining!

Get updates about new method developments, publications and comming events.