Assessment of one-carbon status. Impaired serine metabolism has been assigned a role in psychiatric disorder and neurological disease.
Patient/subject: Prandial status affects concentration, which increases slightly after a protein rich meal.
Matrix: Serum or EDTA plasma. The concentration is about 25 % higher in serum than in plasma.
Volume: Minimum volume is 50 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: There is a time-dependent increase in serine in serum.
Reported values: 95-200 µmol/L.
Intraclass correlation coefficient (ICC): 0.71.
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