BEVITAL AS
Targeted Metabolomics Services
Trigonelline
Updated 23/05/2024
What is measured?
What is trigonelline?
Trigonelline is a phytohormone particularly abundant in coffee beans, and is a marker of coffee consumption (2, 3, 4). Roasting of coffee beans partially converts trigonelline to nicotinic acid. In addition, trigonelline has recently been identified as an NAD+ precursor that improves muscle function and with the potential to treat age-related sarcopentia (PMID 38504132).
Indication(s)
Trigonelline in plasma/serum/urine is a potential marker of coffee consumption.
Specimen, collection and processing
Matrix: Serum, EDTA plasma and urine
Volume: Minimum volume is 60 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: NA.
Transportation
Frozen, on dry ice. (for general instruction on transportation, click here)
Reported values, interpretation
Literature
1. Midttun, O., Hustad, S., and Ueland, P.M. (2009). Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Sp 23, 1371-79.
2. Guertin, K.A., Loftfield, E., Boca, S.M., Sampson, J.N., Moore, S.C., Xiao, Q., Huang, W.Y., Xiong, X., Freedman, N.D., et al. (2015). Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer. Am J Clin Nutr 101, 1000-011.
3. Guertin, K.A., Moore, S.C., Sampson, J.N., Huang, W.Y., Xiao, Q., Stolzenberg-Solomon, R.Z., Sinha, R., and Cross, A.J. (2014). Metabolomics in nutritional epidemiology: identifying metabolites associated with diet and quantifying their potential to uncover diet-disease relations in populations. Am J Clin Nutr 100, 208-217.
4. Midttun, Ø., Ulvik, A., Nygård, O., and Ueland, P.M. (2018). Performance of plasma trigonelline as a marker of coffee consumption in an epidemiologic setting. Am J Clin Nutr 107, 941-47.