BEVITAL AS
Targeted Metabolomics Services
β-Amino-isobutyrate
Updated 30/04/2024
What is measured?
Synonyms: 3-Hydroxyisovaleric acid
Method(s): GC-MS/MS
What is β-Hydroxy β-methylbutyrate?
β-Hydroxy β-methylbutyrate (HMB) is a metabolite of the essential amino acid leucine, used as a dietary supplement to decrease sarcopenia and improve muscle strength. Elevated levels of this compound are found in several inherited disorders. It has been associated with potential health benefits. Mechanisms include activation of mammalian target of rapamycin complex 1 (mTORC1) and increased protein synthesis (1).
Specimen, collection and processing
Patient/subject: No special precaution.
Matrix: Serum or EDTA plasma.
Volume: Minimum volume is 50 µL, but 200 µL is optimal and allows reanalysis.
Preparation and stability: Probably stable.
Transportation
Frozen, on dry ice. (for general instruction on transportation, click here)
Reported values, interpretation
Reported values: 0.1-10, 2-6 (csf) µmol/L
Literature
- Holeček, M. (2017) Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions. J Cachexia Sarcopenia Muscle 8, 529–541.