BEVITAL AS

Pathologies & Physiology

This page provides description of our biomarkers including information on indications, optimal sample collection, volume requirements, sample matrix, recommended conditions for transportation and storage, and interpretation of values.*

Diabetes

Endothelial function

Inflammation

Keton bodies

Liver pathology

Neuroactive

Oncometabolites

Renal function

Uremic toxin

* Reported values are not strictly normal reference range, which depends on the population, and several factors, including age, gender, ethnicity and procedures for sample handling and analytical technology. Reported values are concentrations that we and others have observed or reported in various cohorts of healthy subjects.

March 15, 2024

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Cardiometabolic
Inflammation
Microbiome
Nutrition
Categories
Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs
Tryptophan metabolites, SCFAs, proteins
SCFAs, indoles, choline metabolites, amino acid derived
B-vitamins, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
No. of biomarkers
65
17
20
41
Click to list

Amino acids

  • Alanine
  • Arginine
  • Asparagine
  • Aspartic acid
  • Glutamic acid
  • Glutamine
  • Glycine
  • Histidine
  • Isoleucine
  • Kynurenine
  • Leucine
  • Lysine
  • Methionine
  • Ornithine
  • Phenylalanine
  • Proline
  • Sarcosine
  • Serine
  • Threonine
  • Total cysteine
  • Tryptophan
  • Tyrosine
  • Valine

Amino acids and catabolites

  • 2-Aminoadipic acid
  • 2-Hydroxybutyrate
  • 3-Hydroxysiobutyrate
  • a-Hydroxyglutaric acid
  • B-Alanine
  • B-Aminoisobutyrate
  • B-Hydroxy B-methylbutyric acid
  • Phenylacetylglutamine

Acylcarnities

  • BB Butyrobetaine
  • C0 Carnitine
  • C2 Acetylcarnitine
  • C3 Propionylcarnitine
  • C3-DC Malonylcarnitine
  • C4 Butyrylcarnitine
  • C4-OH Hydroxybutyrylcarnitine
  • C4-DC Succinylcarnitine
  • iC5 Isovalerylcarnitine
  • C5-DC Glutarylcarnitine
  • C5:1 Tiglylcarnitine
  • C6 Hexanoylcarnitine
  • C8 Octanoylcarnitine
  • C10 Decanoylcarnitine
  • C12 Dodecanoylcarnitine
  • C14 Tetradecanoylcarnitine
  • C14-OH Hydroxytetradecanoylcarnitine
  • C16 Hexadecanoylcarnitine
  • C16-OH Hydroxyhexadecanoylcarnitine
  • C18 Octadecanoylcarnitine
  • C18-OH Hydroxyoctadecanoylcarnitine
  • C18:1 Octadecenoylcarnitine
  • C18:2 Octadecadienylcarnitine

TCA metabolites

  • a-Ketoglutarate
  • Citrate
  • Fumarate
  • Isocitrate
  • Lactate
  • Malate
  • Pyruvate

Ketone bodies

  • 3-Hydroxybutyrate
  • Acetoacetate

AGEs

Biomarkers included

Kynurenines

 

Proteins

  • C-Reactive protein
  • Calprotectin
  • Serum Amyloid A

Others

  • Kynurenine/tryptophan ratio
  • Neopterin
  • PAr index (PLP, PL, PA)
Biomarkers included

SCFAs

  • Acetate
  • Butyrate
  • Formate
  • Isobutyrate
  • Isovalerate
  • Propionate
  • Valerate
  • α-Methylbutyrate

Indoles

  • 3-Indoxyl sulfate
  • Imidazole propionate
  • Indole-3-acetamide
  • Indole-3-acetate
  • Indole-3-aldehyde
  • Indole-3-lactate
  • Indole-3-propionate

Choline metabolites

  • Choline
  • Betaine
  • DMG
  • TMAO

Amino acid derived

  • Phenylacetylglutamine
Biomarkers included

B-vitamins, functional markers, and methyl donors

  • 4-Pyridoxic acid
  • Betaine
  • Choline
  • Cobalamin
  • Flavin mononucleotide
  • Folate
  • Methylmalonic acid
  • N1-methylnicotinamide
  • Nicotinamide
  • Nicotinic acid
  • Pyridoxal
  • Pyridoxal 5-phosphate
  • Pyridoxine
  • Riboflavin
  • Thiamine
  • Thiamine monophosphate
  • Total homocysteine

Fat-soluble vitamins

  • 25-hydroxy vitamin D2
  • 25-hydroxy vitamin D3
  • α-Tocopherol (Vit. E)
  • All-trans retinol (Vit. A)
  • Phylloquinone (Vit. K1)
  • y-Tocopherol (Vit. E)

Essential amino acids

  • Histidine
  • Isoleucine
  • Leucine
  • Lysine
  • Methionine
  • Phenylalanine
  • Threonine
  • Tryptophan
  • Valine

Meat and fish intake

  • 1-Methylhistidine
  • 3-Methylhistidine
  • B-Alanine
  • Creatine
  • Creatinine
  • TMAO

Tobacco use and coffee intake

  • Cotinine
  • Trans-3-hydroxycotinine
  • Trigonelline
Volume (ul)
150
100
200
200
Analytical technique
GC- and LC-MS/MS
LC- and MALDI-MS
GC- and LC-MS/MS
GC- and LC-MS/MS
Turnaround time (weeks)
1
1
1
1

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