BEVITAL AS

4 reasons to choose BEVITAL

Academic support

Scientists at BEVITAL have for decades been involved in scientific projects and can provide academic support including collaboration and contributions to writing of funding applications and scientific articles. Formally, BEVITAL is an SME that have been approved as a partner in projects funded by the EU Commission, Norwegian Research Council, Norwegian Cancer Society, National Cancer Institute (US), National Institutes of Health (US), and several other funding.

Experience and track records​

BEVITAL was founded in 2003 by members of a research group with more than 25 years experience in bioanalytical technology, including mass spectrometry. The research group / BEVITAL have been partners in several international projects, including EU funded projects, that involve instrument development, establishment of new technologies, and their application in large epidemiological projects. Recently, BEVITAL has participated in a large multicenter lung cancer study, organized within the frame of the lung cancer consortium (LC3), funded by the National Cancer Institute (US), and including 11000 cases and controls recruited from 20 centers, in Europe, US, Asia, and Australia.
BEVITAL´s analytical repertoire includes methods that have been developed by our scientists and technicians. Most methods have been published in leading scientific journals within the fields of analytical technology, including Clinical Chemistry and Analytical Chemistry. Hence, articles reporting on your project results will include reference(s) to articles in prestigious journals.

Precise and quantitative biomarker profiling

The analytical repertoire of BEVITAL covers defined, cross-talking pathways, cofactors involved, and biomarkers reflecting key lifestyle factors (smoking, meat intake, coffee consumption), nutritional status, kidney and endothelial function and inflammation. Biomarkers are allocated to complementary platforms characterized by multiplexing, high capacity (several thousands samples), large dynamic range (from 1 nM to several mM), and low volume consumption to save precious biobank material. More than 120 biomarkers are measured in less than 500 µL. Notably, all methods based on mass spectrometry include authentic isotope-labelled internal standards, which is paramount to obtain adequate precision and accuracy, as recently reviewed by Khamis et al. These are performances delivered by targeted metabolomics, as opposed to untargeted metabolomics, which capture only abundant metabolites and with the inherent weakness of low capacity, low precision, possible assay interference and misidentification. The high assay precision by use of authentic isotope-labelled internal standards is shown below for a selection of analytes quantified on our GC-MS/MS platform.

Ulvik et al. Anal. Chem. 2021, 93, 7616−7624: Quantifying precision loss in targeted metabolomics based on mass spectrometry and nonmatching internal standards

Low prices due to low costs

Prices of analyses undertaken by BEVITAL are extremely competitive and are kept at production costs. BEVITAL is owned as a whole by a non-profit foundation, supporting research into vitamin deficiency and related topics. There are no private shareholders and therefore no incentive to inflate the cost and thereby the prices. Futhermore, all instrument maintenance and repair are performed by the technical staff of BEVITAL.

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Cardiometabolic
Inflammation
Microbiome
Nutrition
Categories

Amino acids, amino acid catabolites, acylcarnitines, TCA metabolites, ketone bodies, AGEs

Kynurenines, proteins, ratio-derived metabolites



SCFAs, indoles, choline metabolites, amino acid derived



B-vitamins, functional markers, and methyl donors, fat-soluble vitamins, essential amino acids, meat & fish intake, tobacco use & coffee intake
Biomarkers
65
18
20
41
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Amino acids: Alanine, Arginine, Asparagine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Histidine, Isoleucine, Kynurenine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Threonine, Total cysteine, Tryptophan, Tyrosine, Valine

Amino acids and catabolites: 2-Aminoadipic acid, 2-Hydroxybutyrate, 3-Hydroxysiobutyrate, α-Hydroxyglutaric acid, β-Alanine, β-Aminoisobutyrate, β-Hydroxy B-methylbutyric acid, Phenylacetylglutamine

Acylcarnities: BB, C0, C2, C3, C3, DC, C4, C4-OH , C4-DC , iC5 , C5-DC, C5:1 , C6 , C8, C10, C12, C14 , C14-OH, C16, C16-OH, C18 , C18-OH, C18:1, C18:2

TCA metabolites: α-Ketoglutarate, Citrate, Fumarate, Isocitrate, Lactate, Malate, Pyruvate, Ketone bodies, 3-Hydroxybutyrate, Acetoacetate

AGEs: Carboxyethyllysine, Carboxymethyllysine

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Kynurenines: Kynurenine, Kynurenic acid, Quinaldic acid, Anthranilic acid, 3-Hydroxykynurenine, Xanthurenic acid, 3-Hydroxyanthranilic acid, Picolinic acid, Quinolinic acid, Nicotinic acid, Nicotinamide, N1-methylnicotinamide

Neopterin

Proteins: C-Reactive protein, Calprotectin, Serum Amyloid A

Ratio-derived: Kynurenine/tryptophan ratio, PAr index (PLP, PL, PA)

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SCFAs: Acetate, Butyrate, Formate, Isobutyrate, Isovalerate, Propionate, Valerate, α-Methylbutyrate

Indoles: 3-Indoxyl sulfate, Imidazole propionate, Indole-3-acetamide, Indole-3-acetate, Indole-3-aldehyde, Indole-3-lactate, Indole-3-propionate

Choline metabolites: Choline ,Betaine, DMG, TMAO

Amino acid derived: Phenylacetylglutamine

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B-vitamins, functional markers, and methyl donors: 4-Pyridoxic acid, Betaine, Choline, Cobalamin, Flavin mononucleotide, Folate, Methylmalonic acid, N1-methylnicotinamide, Nicotinamide, Nicotinic acid, Pyridoxal, Pyridoxal 5-phosphate, Pyridoxine, Riboflavin, Thiamine, Thiamine monophosphate, Total homocysteine

Fat-soluble vitamins: 25-hydroxy vitamin D2, 25-hydroxy vitamin D3, α-Tocopherol (Vit. E), All-trans retinol (Vit. A), Phylloquinone (Vit. K1), y-Tocopherol (Vit. E)

Essential amino acids: Histidine, Isoleucine, Leucine, Lysine, Methionine, Phenylalanine, Threonine, Tryptophan, Valine

Meat and fish intake: 1-Methylhistidine, 3-Methylhistidine, B-Alanine, Creatine, Creatinine, TMAO

Tobacco use and coffee intake: Cotinine, Trans-3-hydroxycotinine, Trigonelline

Volume (ul)
150
100
200
200
Analytical technique
GC- and LC-MS/MS
LC- and MALDI-MS
GC- and LC-MS/MS
GC- and LC-MS/MS
Turnaround time (weeks)
1
1
1
1

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