BEVITAL AS

BEVITAL AS

Decoding Metabolism’s Impact on Health, Disease and Quality of Life
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Legacy & Vision

Bevital AS, established in 2003 by researchers from the University of Bergen, operates as a non-profit organization. The company’s founders began developing proprietary analytical techniques for examining B vitamins and one-carbon metabolism as early as the 1980s. For more than 2 decades, Bevital has provided novel, high-quality metabolomics services, translating metabolomics data from the laboratory to real-world settings, helping researchers to understand how metabolism impacts health and quality of life.

Our mission is to empower researchers, clinicians, and industry leaders with high-quality, targeted metabolomics data to drive advancements in health, nutrition, and disease prevention. Bevital is committed to scientific excellence, operational integrity, and collaborative innovation to transform metabolic insights into impactful solutions for human health.

Scientific Contribution & Analytical Approaches

Bevital’s group has a strong track record of providing high-precision and reliable metabolomics data to research institutions and industries worldwide investigating nutrition, cardiovascular diseases, cancer, and neurodegenerative conditions. Our analytical repertoire has been established carefully and strategically, targeting established biomarkers, specific metabolites, classes, and important metabolic pathways related to processes ranging from energy homeostasis and cellular function to inflammation, immune activation, and the gut microbiome.

Bevital’s scientific contribution to many international projects has demonstrated that assay precision, accuracy, and reliability are crucial for achieving project outcomes. All our methods are developed using authentic isotope labelled internal standards for each analyte, providing absolute quantification of the highest quality on the market. Our targeted metabolomics panels have been designed to be analytically and biologically complementary and are established across dedicated GC- and LC-MS/MS platforms. Our approach allows quantification of diverse, but related classes of both high- and low-abundance metabolites.

Tailored Solutions & Services

We offer different analytical packages to meet changing research needs and demands. Ready-to-run panels allow customers to choose between pre-designed solutions at lower costs. Researchers requiring greater flexibility can mix different metabolites from Bevital’s repertoire and compose individual panels specific to the demands of their project. Metabolites of interest not yet included may be incorporated into existing assays or established as customized targeted analyses.

As a service provider for Olink Proteomics and a partner of Biogenity, we’re equipped to deliver comprehensive Omics data and analysis services. These offerings will empower our customers to uncover novel insights from their data by integrating multiple omics approaches — not just relying on metabolomics or proteomics alone. We believe these services will significantly enhance research outcomes. Bevital offers full academic project support, from the writing of grant applications and study planning, to sample analysis, data interpretation, and critical review of manuscripts.

The Team

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Per Christian Eriksen

Øivind

Per Magne Ueland has been Professor at the University of Bergen 1987-2018. He is one of the founders of Bevital AS and the scientific advisor in Bevital since 2023. His interests includes biomarkers related to nutrition, inflammation, ageing and life-style related chronic diseases. Per is committed to the development of precise, high-throughput mass spectrometry methods, tailored for metabolic profiling of biobank specimens from large cohorts.

Ove completed his education in Biomedical Science at the Western Norway University of Applied Sciences, supplemented by specialized training in Electrical Engineering and Electronics at the Royal Norwegian Naval Training Establishment and the National Institute of Technology. With many years of experience as a biomedical scientist in hospital laboratories—specializing primarily in microbiology—he brings a unique blend of clinical and technical expertise to his work. Ove focuses on the design and prototyping of electronics, as well as the service and maintenance of laboratory instrumentation, ensuring that technical equipment and workflows remain precise and reliable for research-focused activities.

Lena holds a master`s degree in biology from the University in Bergen. At Bevital she works with LC-MS/MS anlyses focusing on accurate and reliable testing of biological samples. She is dedicated to ensuring precise and high-quality results that contribute to reliable scientific outcomes and support ongoing research efforts.

Marit holds a degree in chemical engineering from Bergen Ingeniørhøyskole, which is now part of the Western Norway University of Applied Sciences. She works with quantitative analysis and method development on LC-MS/MS at the laboratory of Bevital AS.

Ove completed a bachelor’s degree in Biomedical Laboratory Sciences at the Western Norway University of Applied Sciences in Bergen. With extensive experience in method development and expertise in GC-MS/MS, he specializes in optimizing analytical techniques for research-focused studies. At Bevital, Ove is dedicated to advancing laboratory methods and workflows, contributing to innovative research through precise and reliable analytical solutions.

Lene holds a bachelor’s degree in Biomedical Laboratory Science from the Western Norway University of Applied Sciences, where she is also completing her master’s degree in Medical Laboratory Technology. At Bevital, she works with GC-MS/MS analyses, focusing on accurate and reliable testing of biological samples. With her strong laboratory background, Lene is committed to delivering high-quality results that support medical research.

Klaus holds a PhD in physics from the University of Münster in Germany. He has over three decades of experience in Time-of-Flight mass spectrometry. He leverages his extensive expertise to provide customers with cutting-edge MALDI-MS analysis and the newest Olink Proteomics services.

Adrian holds a PhD in diabetes research, along with bachelor’s and master’s degrees in biomedical science and public health, respectively. With over 20 years of experience in laboratory science, he leads high-precision metabolite analyses and method development at Bevital. His expertise centers on quantifying biomarkers, metabolite classes, and metabolic pathways related to nutrition, cardiovascular and neurodegenerative diseases, and cancer. Adrian is committed to advancing research quality and actively collaborates nationally and internationally, leveraging targeted metabolomics to support innovative, multidisciplinary research.

Statistical power is the probability that a statistical test will correctly reject a false null hypothesis (H0​) when a specific alternative hypothesis (H1​) is true. H0​ is the null hypothesis, which states there is no effect or no difference. H1​ is the alternative hypothesis, which states there is a real effect or difference. Alpha (α) is the probability of a Type I error (a false positive), which is the risk of incorrectly rejecting the H0​ when it is actually true. You set this value before the experiment, commonly at 0.05. Beta (β) is the probability of a Type II error (a false negative), which is the risk of failing to reject the H0​ when it is actually false.

Power is calculated as 1−β. Increasing power means you are decreasing the probability of making a Type II error.

Several factors can be adjusted to increase the power of a statistical test:

  • Effect Size: This is the magnitude of the difference you are trying to detect. A larger effect size is easier to detect, thus increasing power. 

  • Sample Size: The number of observations in a study. A larger sample size provides more information about the population, reducing the margin of error and increasing the power to detect a true effect.

  • Variation: Refers to the spread or standard deviation of the data within the population. Less variation makes it easier to distinguish a real effect from random noise, thereby increasing power.

  • Alpha (): Increasing the alpha level (e.g., from 0.05 to 0.10) also increases power, but at the cost of a higher risk of a Type I error. This trade-off is often undesirable.

579 entries « 1 of 29 »
1.

Walzik, David; Wenzel, Charlotte; Strotkötter, Jule Elisabeth; Hoenen, Leon; Chirino, Tiffany Y Wences; Trebing, Sina; McCann, Adrian; Ueland, Per Magne; Zimmer, Philipp; Joisten, Niklas

Systemic metabolite kinetics mirror skeletal muscle energy metabolism during acute aerobic exercise Journal Article

In: Am J Physiol Cell Physiol, vol. 330, no. 1, pp. C111–C118, 2026, ISSN: 1522-1563.

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2.

Klaassen-Dekker, Niels; Zoetendal, Erwin G; Capuano, Edoardo; Winkels, Renate M; van Duijnhoven, Fränzel Jb; van Heek, N Tjarda; Kruyt, Flip M; Ulvik, Arve; McCann, Adrian; Ueland, Per Magne; de Wilt, Johannes Hw; Kampman, Ellen; Kok, Dieuwertje E

Preoperative plasma short- and branched-chain fatty acids in relation to risk of complications after colorectal cancer surgery: a prospective cohort study Journal Article

In: Am J Clin Nutr, vol. 122, no. 6, pp. 1579–1590, 2025, ISSN: 1938-3207.

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3.

Linde, Anja; Gerdts, Eva; Fevang, Bjørg T; Ulvik, Arve; Ueland, Per M; Meyer, Klaus; Kringeland, Ester; Midtbø, Helga

Factors associated with left ventricular mass during disease modifying antirheumatic drug therapy in patients with rheumatoid arthritis: the Joint Heart study Journal Article

In: Int J Cardiol Cardiovasc Risk Prev, vol. 27, pp. 200521, 2025, ISSN: 2772-4875.

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4.

Wenzel, Charlotte; Walzik, David; Wences, Tiffany; Trebing, Sina; Meyer, Klaus; Groll, Andreas; Zimmer, Philipp; Joisten, Niklas

Immunological Protein Signature During Acute Exercise Journal Article

In: Acta Physiol (Oxf), vol. 241, no. 12, pp. e70125, 2025, ISSN: 1748-1716.

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5.

Kvestad, Ingrid; Ulak, Manjeswori; McCann, Adrian; Chandyo, Ram K; Hysing, Mari; Schwinger, Catherine; Ranjitkar, Suman; Ueland, Per Magne; Basnet, Sudha; Strand, Tor A

The effect of vitamin B12 supplementation during pregnancy on early motor performance. Secondary analyses from a double-blinded randomized controlled trial Journal Article

In: J Nutr, pp. 101305, 2025, ISSN: 1541-6100.

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6.

Kupjetz, Marie; Langeskov-Christensen, Martin; Riemenschneider, Morten; Inerle, Stefan; Ligges, Uwe; Gaemelke, Tobias; Patt, Nadine; Bansi, Jens; Gonzenbach, Roman Rudolf; Reuter, Marcel; Rosenberger, Friederike; Meyer, Tim; McCann, Adrian; Ueland, Per Magne; Eskildsen, Simon Fristed; Nygaard, Mikkel Karl Emil; Joisten, Niklas; Hvid, Lars; Dalgas, Ulrik; Zimmer, Philipp

Persons With Multiple Sclerosis Reveal Distinct Kynurenine Pathway Metabolite Patterns: A Multinational Cross-Sectional Study Journal Article

In: Neurol Neuroimmunol Neuroinflamm, vol. 12, no. 6, pp. e200461, 2025, ISSN: 2332-7812.

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7.

Sandvig, Heidi Vihovde; Saltvedt, Ingvild; Edwin, Trine Holt; Aam, Stina; Alme, Katinka Nordheim; Eldholm, Rannveig Sakshaug; Lydersen, Stian; Mollnes, Tom Eirik; Munthe-Kaas, Ragnhild; Ueland, Per Magne; Ulvik, Arve; Wethal, Torgeir; Knapskog, Anne-Brita

Associations between systemic inflammation and cognitive trajectories post-stroke Journal Article

In: Sci Rep, vol. 15, no. 1, pp. 42791, 2025, ISSN: 2045-2322.

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8.

Knudsen, Andreas Dehlbæk; Gelpi, Marco; Suarez-Zdunek, Moises A; Loft, Josefine A; Ueland, Per Magne; Ostrowski, Sisse Rye; Midttun, Øivind; Martinez, Esteban; Nielsen, Susanne D

Inhibition of Th1-type immune responses in persons with HIV with current statin exposure Journal Article

In: AIDS, 2025, ISSN: 1473-5571.

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9.

Bråtveit, Marianne; Strømland, Pouda P; Laupsa-Borge, Johnny; Skumsnes, Lillian; Dagsland, Vigdis H; Kvistad, Silje; Vogt, Elinor C; McCann, Adrian; Thorsen, Håvard L; Diamantopoulos, Andreas P; Nedrebø, Bjørn Gunnar; Mellgren, Gunnar; Dankel, Simon N

A Very-Low Energy Fast Involves Increased Adipose Inflammatory Gene Expression: A 6-Day Feeding Trial (FASTOMICS-6) Journal Article

In: J Clin Endocrinol Metab, 2025, ISSN: 1945-7197.

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10.

Dhar, Indu; Svingen, Gard Ft; Ulvik, Arve; Bjørnestad, Espen Ø; Sagen, Jørn V; Nygård, Ottar K

Serum Vitamin A Is Associated with Variations in the Relationship between Plasma B6 Vitamers and Cardiovascular Disease Risk Journal Article

In: J Nutr, 2025, ISSN: 1541-6100.

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11.

Jørgensen, Silje F; Braadland, Peder R; Ueland, Thor; Fraz, Mai S A; Michelsen, Annika E; Holm, Kristian; Osnes, Liv T; Trøseid, Marius; Ueland, Per Magne; Fevang, Børre; Aukrust, Pål; Hov, Johannes R

Tryptophan-kynurenine metabolites associate with inflammation and immunologic phenotypes in common variable immunodeficiency Journal Article

In: J Allergy Clin Immunol, vol. 156, no. 3, pp. 814–824.e11, 2025, ISSN: 1097-6825.

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12.

Vilar, Ana; Bayes-Marin, Ivet; Álvarez-Salazar, Samantha; Piqueras-Marques, Jorge; Vila, Santiago Batlle; Forero, Carlos G

Prevalence of depressive symptoms in the general population with a fully structured interview with skips vs. unconditional sequential assessment: implications for clinical and psychiatric epidemiology studies Journal Article

In: J Psychiatr Res, vol. 189, pp. 424–434, 2025, ISSN: 1879-1379.

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13.

Bjørkevoll, Sol Maja G; O'Keeffe, Maria; Konijnenberg, Carolien; Solvik, Beate S; Sødal, Alida F; Kaldenbach, Siri; McCann, Adrian; Ueland, Per M; Kvestad, Ingrid; Ersvær, Elisabeth; Holten-Andersen, Mads N; Bakken, Kjersti S; Strand, Tor A

Infant vitamin B12 status and its predictors - cross-sectional baseline results from an ongoing randomized controlled trial Journal Article

In: Am J Clin Nutr, vol. 122, no. 3, pp. 803–810, 2025, ISSN: 1938-3207.

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14.

Holthuijsen, Daniëlle D B; van Roekel, Eline H; Bours, Martijn J L; Ueland, Per M; Breukink, Stéphanie O; Janssen-Heijnen, Maryska L G; Konsten, Joop L; Keulen, Eric T P; McCann, Adrian; Brezina, Stefanie; Gigic, Biljana; Kok, Dieuwertje E; Ulrich, Cornelia M; Weijenberg, Matty P; Eussen, Simone J P M

Modeling how iso-caloric macronutrient substitutions are longitudinally associated with plasma kynurenines in colorectal cancer survivors up to 12 months post-treatment Journal Article

In: J Nutr Biochem, vol. 141, pp. 109910, 2025, ISSN: 1873-4847.

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15.

Valim, Valéria; Oliveira, Fabíola R; Miyamoto, Samira T; Serrano, Érica V; Balarini, Gabriela M; Tanure, Leandro A; Ferreira, Gilda A; Zandonade, Eliana; Brun, Johan G; Jonsson, Malin; Maeland, Elisabeth; Ulvik, Arve; Ueland, Per Magne; Jonsson, Roland; Mydel, Piotr M

Kynurenines and neopterin are interferon-gamma-inducible biomarkers for Sjögren's disease Journal Article

In: Rheumatology (Oxford), vol. 64, no. 7, pp. 4404–4413, 2025, ISSN: 1462-0332.

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16.

Bakker, Lieke; Ramakers, Inez H G B; van Greevenbroek, Marleen M J; Backes, Walter H; Jansen, Jacobus F A; Schram, Miranda T; van der Kallen, Carla J H; Schalkwijk, Casper G; Wesselius, Anke; Ulvik, Arve; Ueland, Per M; Verhey, Frans R J; Eussen, Simone J P M; Köhler, Sebastian

The kynurenine pathway and markers of neurodegeneration and cerebral small vessel disease: The Maastricht Study Journal Article

In: J Neurol Sci, vol. 474, pp. 123522, 2025, ISSN: 1878-5883.

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17.

Gordon, Shane; Hoey, Leane; McNulty, Helene; Keenan, Jordan; Pangilinan, Faith; Brody, Lawrence C; Ward, Mary; Strain, J J; McAnena, Liadhan; McCann, Adrian; Molloy, Anne M; Cunningham, Conal; McCarroll, Kevin; Hughes, Catherine F

Associations of one-carbon metabolism, related B-vitamins and ApoE genotype with cognitive function in older adults: identification of a novel gene-nutrient interaction Journal Article

In: BMC Med, vol. 23, no. 1, pp. 440, 2025, ISSN: 1741-7015.

Abstract | Links | BibTeX

18.

Belen, Sergen; Patt, Nadine; Kupjetz, Marie; Ueland, Per M; McCann, Adrian; Gonzenbach, Roman; Bansi, Jens; Zimmer, Philipp

Vitamin B status is related to disease severity and modulated by endurance exercise in individuals with multiple sclerosis: a secondary analysis of a randomized controlled trial Journal Article

In: Am J Clin Nutr, vol. 121, no. 6, pp. 1403–1414, 2025, ISSN: 1938-3207.

Abstract | Links | BibTeX

19.

Dahl, Tuva B; Aftab, Friha; Prebensen, Christian; Berdal, Jan-Erik; Ueland, Thor; Barratt-Due, Andreas; Riise, Anne Ma Dyrhol; Ueland, Per Magne; Hov, Johannes R; Trøseid, Marius; Aukrust, Pål; Gregersen, Ida; Myhre, Peder L; Omland, Torbjørn; Halvorsen, Bente

Imidazole propionate is increased in severe COVID-19 and correlates with cardiac involvement Miscellaneous

2025, ISSN: 1532-2742.

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20.

Park, Jin Young; Puyvelde, Heleen Van; Regazzetti, Lea; Clasen, Joanna L; Heath, Alicia K; Eussen, Simone; Ueland, Per Magne; Johansson, Mattias; Biessy, Carine; Zamora-Ros, Raul; Huerta, José María; Sánchez, Maria-Jose; Ocke, Marga; Schulze, Matthias B; Schiborn, Catarina; Braaten, Tonje Bjørndal; Skeie, Guri; Sacerdote, Carlotta; Castilla, Jesús; Karlsson, Therese; Johansson, Ingegerd; Kyrø, Cecilie; Tjønneland, Anne; Tong, Tammy Y N; Katzke, Verena; Bajracharya, Rashmita; Lasheras, Cristina; Midttun, Øivind; Vollset, Stein Emil; Vineis, Paolo; Masala, Giovanna; Amiano, Pilar; Tumino, Rosario; Baldassari, Ivan; Weiderpass, Elisabete; Riboli, Elio; Gunter, Marc J; Freisling, Heinz; Rinaldi, Sabina; Muller, David C; Huybrechts, Inge; Ferrari, Pietro

Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition Journal Article

In: Nutrients, vol. 17, no. 12, 2025, ISSN: 2072-6643.

Abstract | Links | BibTeX

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