Targeted Metabolomics Services

High performance GC-MS/MS of

Tricarboxylic acid cycle and related metabolites

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The tricarboxylic acid (TCA) cycle is

a series of reactions forming a loop that ultimately generate energy, mainly by oxidation of acetyl-CoA generated from glycolysis, and catabolism of fatty acids and amino acids. Studies on metabolomics involving Krebs cycle intermediates in relation to human health and disease usually include few patients and have been performed only recently. These metabolites have been related to BMI, cardiovascular disease (pyruvate, citrate, succinate), diabetes (pyruvate, isocitrate, succinate), NAFLD (isocitrate and citrate), longevity (isocitrate), asthma (succinate), disease activity in rheumatoid arthritis patients (itaconate), and worsening of clinical outcome in cancer patients (succinate, fumarate and α-hydroxyglutarate)

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BEVITAL offers analyses of

 

α-ketoglutarate, citrate, fumarate, isocitrate, lactate, malate, and pyruvate in 60 µl of plasma or serum samples.

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Why choosing BEVITAL?

High-precision data by use of authentic isotope-labelled IS

More than 20 years of experience in chromatography and MS

Scientific support from analysis planning to data interpretation

Track record in international, EU-, and NIH-funded projects

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20 %

Median CV on
GC-MS/MS

20 %

Median CV on
LC-MS/MS

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