BEVITAL AS

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Bevital analyses a range of biological samples for targeted metabolomics, including serum (s), plasma (p), as well as cerebrospinal fluid (CSF), urine (u), and whole blood (w) for selected biomarkers. The analytical platforms are tailored to accommodate these sample types, focusing on high precision and minimal sample consumption. Please contact us regarding analyses from cell and tissue extracts.

Ready-to-Run packageMethodVolumeMatrix
CardiometabolicGC and LC-MS/MS200 µLs, p, csf
Inflammation & Immune ActivationGC-MS/MS and MALDI-MS150 µLs, p, csf
MicrobiomeGC and LC-MS/MS250 µLs, p, csf
Nutritional Status & LifestyleGC and LC-MS/MS300 µLs, p, csf
PlatformAnalytesMethodVolumeMatrix
AShort-chain fatty acidsGC-MS/MS50 µLs, p ,csf*
BAmino- and carboxylic acids. TCA metabolites and intermediatesGC-MS/MS50 µLs, p ,csf*
CCholine derivatives. Charged, methylated or sulfur amino acidsLC-MS/MS35 µLs, p, u*
DKynurenine pathway and B vitamins, indoles, nicotin, coffee markers, and inflammation markersLC-MS/MS60 µLs, p ,csf*
EFolate species and catabolitesLC-MS/MS60 µLs, p
FFolate (B9) and cobalamin (B12)Microbiological assay15-35 µLs, p
GProtein biomarkers and variantsMALDI-TOF MS30 µLs, p, csf, w*
HLipid-soluble vitaminsLC-MS/MS50-10 µLs, p
IShort-, medium- and long-chain acylcarnitinesLC (HILIC)-MS/MS60 µLs, p
JNAD metabolomeLC (HILIC)-MS/MS50 µLw
KBile acidsLC-MS/MS50 µLs, p

* Not all analytes detectable in all matrices

September 30, 2025
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Per Christian Eriksen

Øivind

Per Magne Ueland has been Professor at the University of Bergen 1987-2018. He is one of the founders of Bevital AS and the scientific advisor in Bevital since 2023. His interests includes biomarkers related to nutrition, inflammation, ageing and life-style related chronic diseases. Per is committed to the development of precise, high-throughput mass spectrometry methods, tailored for metabolic profiling of biobank specimens from large cohorts.

Marit holds a degree in chemical engineering from Bergen Ingeniørhøyskole, which is now part of the Western Norway University of Applied Sciences. She works with quantitative analysis and method development on LC-MS/MS at the laboratory of Bevital AS.

Ove completed a bachelor’s degree in Biomedical Laboratory Sciences at the Western Norway University of Applied Sciences in Bergen. With extensive experience in method development and expertise in GC-MS/MS, he specializes in optimizing analytical techniques for research-focused studies. At Bevital, Ove is dedicated to advancing laboratory methods and workflows, contributing to innovative research through precise and reliable analytical solutions.

Lene holds a bachelor’s degree in Biomedical Laboratory Science from the Western Norway University of Applied Sciences, where she is also completing her master’s degree in Medical Laboratory Technology. At Bevital, she works with GC-MS/MS analyses, focusing on accurate and reliable testing of biological samples. With her strong laboratory background, Lene is committed to delivering high-quality results that support medical research.

Klaus holds a PhD in physics from the University of Münster in Germany. He has over three decades of experience in Time-of-Flight mass spectrometry. He leverages his extensive expertise to provide customers with cutting-edge MALDI-MS analysis and the newest Olink Proteomics services.

Adrian holds a PhD in diabetes research, along with bachelor’s and master’s degrees in biomedical science and public health, respectively. With over 20 years of experience in laboratory science, he leads high-precision metabolite analyses and method development at Bevital. His expertise centers on quantifying biomarkers, metabolite classes, and metabolic pathways related to nutrition, cardiovascular and neurodegenerative diseases, and cancer. Adrian is committed to advancing research quality and actively collaborates nationally and internationally, leveraging targeted metabolomics to support innovative, multidisciplinary research.

Statistical power is the probability that a statistical test will correctly reject a false null hypothesis (H0​) when a specific alternative hypothesis (H1​) is true. H0​ is the null hypothesis, which states there is no effect or no difference. H1​ is the alternative hypothesis, which states there is a real effect or difference. Alpha (α) is the probability of a Type I error (a false positive), which is the risk of incorrectly rejecting the H0​ when it is actually true. You set this value before the experiment, commonly at 0.05. Beta (β) is the probability of a Type II error (a false negative), which is the risk of failing to reject the H0​ when it is actually false.

Power is calculated as 1−β. Increasing power means you are decreasing the probability of making a Type II error.

Several factors can be adjusted to increase the power of a statistical test:

  • Effect Size: This is the magnitude of the difference you are trying to detect. A larger effect size is easier to detect, thus increasing power. 

  • Sample Size: The number of observations in a study. A larger sample size provides more information about the population, reducing the margin of error and increasing the power to detect a true effect.

  • Variation: Refers to the spread or standard deviation of the data within the population. Less variation makes it easier to distinguish a real effect from random noise, thereby increasing power.

  • Alpha (): Increasing the alpha level (e.g., from 0.05 to 0.10) also increases power, but at the cost of a higher risk of a Type I error. This trade-off is often undesirable.

562 entries « 2 of 29 »
21.

Sulistyoningrum, Dian C; Sullivan, Thomas R; Skubisz, Monika; Palmer, Debra J; Wood, Simon; Ueland, Per Magne; McCann, Adrian; Makrides, Maria; Green, Timothy J; Best, Karen P

Maternal serum unmetabolized folic acid concentration following multivitamin and mineral supplementation with or without folic acid after 12 weeks gestation: A randomized controlled trial Journal Article

In: Matern Child Nutr, vol. 20, no. 4, pp. e13668, 2024, ISSN: 1740-8709.

Abstract | Links | BibTeX

22.

Wilson, Edward; Umans, Jacob; Swarovski, Michelle; Minhas, Paras; Midttun, Øivind; Ulvik, Arve Arve; Shahid-Besanti, Marian; Linortner, Patricia; Mhatre, Siddhita; Wang, Qian; Channappa, Divya; Corso, Nicole; Tian, Lu; Fredericks, Carolyn; Kerchner, Geoffrey; Plowey, Edward; Cholerton, Brenna; Ueland, Per; Zabetian, Cyrus; Gray, Nora; Quinn, Joseph; Montine, Thomas; Sha, Sharon; Longo, Frank; Wolk, David; Chen-Plotkin, Alice; Henderson, Victor; Wyss-Coray, Tony; Wagner, Anthony; Mormino, Elizabeth; Aghaeepour, Nima; Poston, Kathleen; Andreasson, Katrin

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction Journal Article

In: Res Sq, 2024, ISSN: 2693-5015.

Abstract | Links | BibTeX

23.

Midtbø, Helga; Ulvik, Arve; Cramariuc, Dana; Meyer, Klaus; Ueland, Per M; Halland, Hilde; Gerdts, Eva

Influence of cardiorespiratory fitness on obesity-associated inflammation in women and men: The FATCOR study Journal Article

In: Nutr Metab Cardiovasc Dis, vol. 34, no. 8, pp. 1942–1949, 2024, ISSN: 1590-3729.

Abstract | Links | BibTeX

24.

Ulak, Manjeswori; Kvestad, Ingrid; Chandyo, Ram K; Schwinger, Catherine; Basnet, Sudha; Shrestha, Merina; Ranjitkar, Suman; Nguyen, Linda Vy; Corona-Pérez, Diana; Vivo, Immaculata De; Ueland, Per M; McCann, Adrian; Strand, Tor A

The Effect of Vitamin B Supplementation on Leukocyte Telomere Length in Mildly Stunted Nepalese Children: A Secondary Outcome of a Randomized Controlled Trial Journal Article

In: J Nutr, vol. 154, no. 8, pp. 2543–2550, 2024, ISSN: 1541-6100.

Abstract | Links | BibTeX

25.

Knapskog, Anne-Brita; Edwin, Trine Holt; Ueland, Per Magne; Ulvik, Arve; Fang, Evandro Fei; Eldholm, Rannveig Sakshaug; Halaas, Nathalie Bodd; Giil, Lasse M; Saltvedt, Ingvild; Watne, Leiv Otto; Aksnes, Mari

Sex-specific associations of kynurenic acid with neopterin in Alzheimer's disease Journal Article

In: Alzheimers Res Ther, vol. 16, no. 1, pp. 167, 2024, ISSN: 1758-9193.

Abstract | Links | BibTeX

26.

Pluvinage, John V; Ngo, Thomas; Fouassier, Camille; McDonagh, Maura; Holmes, Brandon B; Bartley, Christopher M; Kondapavulur, Sravani; Hurabielle, Charlotte; Bodansky, Aaron; Pai, Vincent; Hinman, Sam; Aslanpour, Ava; Alvarenga, Bonny D; Zorn, Kelsey C; Zamecnik, Colin; McCann, Adrian; Asencor, Andoni I; Huynh, Trung; Browne, Weston; Tubati, Asritha; Haney, Michael S; Douglas, Vanja C; Louine, Martineau; Cree, Bruce A C; Hauser, Stephen L; Seeley, William; Baranzini, Sergio E; Wells, James A; Spudich, Serena; Farhadian, Shelli; Ramachandran, Prashanth S; Gillum, Leslie; Hales, Chadwick M; Zikherman, Julie; Anderson, Mark S; Yazdany, Jinoos; Smith, Bryan; Nath, Avindra; Suh, Gina; Flanagan, Eoin P; Green, Ari J; Green, Ralph; Gelfand, Jeffrey M; DeRisi, Joseph L; Pleasure, Samuel J; Wilson, Michael R

Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency Journal Article

In: Sci Transl Med, vol. 16, no. 753, pp. eadl3758, 2024, ISSN: 1946-6242.

Abstract | Links | BibTeX

27.

Bråtveit, Marianne; Parys, Anthea Van; Olsen, Thomas; Strand, Elin; Marienborg, Ingvild; Laupsa-Borge, Johnny; Haugsgjerd, Teresa Risan; McCann, Adrian; Dhar, Indu; Ueland, Per Magne; Dierkes, Jutta; Dankel, Simon Nitter; Nygård, Ottar Kjell; Lysne, Vegard

Association between dietary macronutrient composition and plasma one-carbon metabolites and B-vitamin cofactors in patients with stable angina pectoris Journal Article

In: Br J Nutr, vol. 131, no. 10, pp. 1678–1690, 2024, ISSN: 1475-2662.

Abstract | Links | BibTeX

28.

Holthuijsen, Daniëlle D B; van Roekel, Eline H; Bours, Martijn J L; Ueland, Per M; Breukink, Stéphanie O; Janssen-Heijnen, Maryska L G; Keulen, Eric T P; Gigic, Biljana; Gsur, Andrea; Meyer, Klaus; Ose, Jennifer; Ulvik, Arve; Weijenberg, Matty P; Eussen, Simone J P M

Longitudinal associations of plasma kynurenines and ratios with anxiety and depression scores in colorectal cancer survivors up to 12 months post-treatment Journal Article

In: Psychoneuroendocrinology, vol. 163, pp. 106981, 2024, ISSN: 1873-3360.

Abstract | Links | BibTeX

29.

Sandvig, Heidi Vihovde; Aam, Stina; Alme, Katinka N; Lydersen, Stian; Ueland, Per Magne; Ulvik, Arve; Wethal, Torgeir; Saltvedt, Ingvild; Knapskog, Anne-Brita

Neopterin, kynurenine metabolites, and indexes related to vitamin B6 are associated with post-stroke cognitive impairment: The Nor-COAST study Journal Article

In: Brain Behav Immun, vol. 118, pp. 167–177, 2024, ISSN: 1090-2139.

Abstract | Links | BibTeX

30.

Senkin, Sergey; Moody, Sarah; Díaz-Gay, Marcos; Abedi-Ardekani, Behnoush; Cattiaux, Thomas; Ferreiro-Iglesias, Aida; Wang, Jingwei; Fitzgerald, Stephen; Kazachkova, Mariya; Vangara, Raviteja; Le, Anh Phuong; Bergstrom, Erik N; Khandekar, Azhar; Otlu, Burçak; Cheema, Saamin; Latimer, Calli; Thomas, Emily; Atkins, Joshua Ronald; Smith-Byrne, Karl; Penha, Ricardo Cortez Cardoso; Carreira, Christine; Chopard, Priscilia; Gaborieau, Valérie; Keski-Rahkonen, Pekka; Jones, David; Teague, Jon W; Ferlicot, Sophie; Asgari, Mojgan; Sangkhathat, Surasak; Attawettayanon, Worapat; Świątkowska, Beata; Jarmalaite, Sonata; Sabaliauskaite, Rasa; Shibata, Tatsuhiro; Fukagawa, Akihiko; Mates, Dana; Jinga, Viorel; Rascu, Stefan; Mijuskovic, Mirjana; Savic, Slavisa; Milosavljevic, Sasa; Bartlett, John M S; Albert, Monique; Phouthavongsy, Larry; Ashton-Prolla, Patricia; Botton, Mariana R; Neto, Brasil Silva; Bezerra, Stephania Martins; Curado, Maria Paula; de Cássio Zequi, Stênio; Reis, Rui Manuel; Faria, Eliney Ferreira; de Menezes, Nei Soares; Ferrari, Renata Spagnoli; Banks, Rosamonde E; Vasudev, Naveen S; Zaridze, David; Mukeriya, Anush; Shangina, Oxana; Matveev, Vsevolod; Foretova, Lenka; Navratilova, Marie; Holcatova, Ivana; Hornakova, Anna; Janout, Vladimir; Purdue, Mark P; Rothman, Nathaniel; Chanock, Stephen J; Ueland, Per Magne; Johansson, Mattias; McKay, James; Scelo, Ghislaine; Chanudet, Estelle; Humphreys, Laura; de Carvalho, Ana Carolina; Perdomo, Sandra; Alexandrov, Ludmil B; Stratton, Michael R; Brennan, Paul

Geographic variation of mutagenic exposures in kidney cancer genomes Journal Article

In: Nature, vol. 629, no. 8013, pp. 910–918, 2024, ISSN: 1476-4687.

Abstract | Links | BibTeX

31.

Strand, Tor A; McCann, Adrian; Kvestad, Ingrid; Chandyo, Ram K

Vitamin B12 deficiency in pregnant women - Authors' reply Miscellaneous

2024, ISSN: 1474-547X.

Links | BibTeX

32.

Anfinsen, Åslaug Matre; Johannesen, Christina Osland; Myklebust, Vilde Haugen; Rosendahl-Riise, Hanne; McCann, Adrian; Nygård, Ottar Kjell; Dierkes, Jutta; Lysne, Vegard

Time-resolved concentrations of serum amino acids, one-carbon metabolites and B-vitamin biomarkers during the postprandial and fasting state: the Postprandial Metabolism in Healthy Young Adults (PoMet) Study Journal Article

In: Br J Nutr, vol. 131, no. 5, pp. 786–800, 2024, ISSN: 1475-2662.

Abstract | Links | BibTeX

33.

Rim, Sehee; Vedøy, Oda Barth; Brønstad, Ingeborg; McCann, Adrian; Meyer, Klaus; Steinsland, Hans; Hanevik, Kurt

Inflammation, the kynurenines, and mucosal injury during human experimental enterotoxigenic Escherichia coli infection Journal Article

In: Med Microbiol Immunol, vol. 213, no. 1, pp. 2, 2024, ISSN: 1432-1831.

Abstract | Links | BibTeX

34.

Trøseid, Marius; Molinaro, Antonio; Gelpi, Marco; Vestad, Beate; Kofoed, Klaus Fuglsang; Fuchs, Andreas; Køber, Lars; Holm, Kristian; Benfield, Thomas; Ueland, Per M; Hov, Johannes R; Nielsen, Susanne Dam; Knudsen, Andreas Dehlbæk

Gut Microbiota Alterations and Circulating Imidazole Propionate Levels Are Associated With Obstructive Coronary Artery Disease in People With HIV Journal Article

In: J Infect Dis, vol. 229, no. 3, pp. 898–907, 2024, ISSN: 1537-6613.

Abstract | Links | BibTeX

35.

Kok, Dieuwertje E; van Duijnhoven, Fränzel Jb; Lubberman, Floor Je; McKay, Jill A; van Lanen, Anne-Sophie; Winkels, Renate M; Wesselink, Evertine; van Halteren, Henk K; de Wilt, Johannes Hw; Ulrich, Cornelia M; Ulvik, Arve; Ueland, Per M; Kampman, Ellen

Intake and biomarkers of folate and folic acid as determinants of chemotherapy-induced toxicities in patients with colorectal cancer: a cohort study Journal Article

In: Am J Clin Nutr, vol. 119, no. 2, pp. 294–301, 2024, ISSN: 1938-3207.

Abstract | Links | BibTeX

36.

Raju, Sajan C; Molinaro, Antonio; Awoyemi, Ayodeji; Jørgensen, Silje F; Braadland, Peder R; Nendl, Andraz; Seljeflot, Ingebjørg; Ueland, Per M; McCann, Adrian; Aukrust, Pål; Vestad, Beate; Mayerhofer, Cristiane; Broch, Kaspar; Gullestad, Lars; Lappegård, Knut T; Halvorsen, Bente; Kristiansen, Karsten; Hov, Johannes R; Trøseid, Marius

Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity Journal Article

In: Genome Med, vol. 16, no. 1, pp. 27, 2024, ISSN: 1756-994X.

Abstract | Links | BibTeX

37.

Braadland, Peder R; Farnes, Ingvild; Kure, Elin H; Yaqub, Sheraz; McCann, Adrian; Ueland, Per M; Labori, Knut Jørgen; Hov, Johannes R

Indole 3-acetate and response to therapy in borderline resectable or locally advanced pancreatic cancer Journal Article

In: Front Oncol, vol. 14, pp. 1488749, 2024, ISSN: 2234-943X.

Abstract | Links | BibTeX

38.

Giil, Lasse Melvaer; Hanseth, Silja; Bojovic, Ognjen; Nordrehaug, Jan Erik; Ueland, Per Magne; Meyer, Klaus; Tell, Grethe S

The inverse association between the apolipoprotein E ε4 allele and C-reactive protein levels is stronger in persons with obesity and diabetes Journal Article

In: Scand J Immunol, vol. 99, no. 1, pp. e13323, 2024, ISSN: 1365-3083.

Abstract | Links | BibTeX

39.

Grymyr, Lisa M D; Mellgren, Gunnar; McCann, Adrian; Gerdts, Eva; Meyer, Klaus; Nadirpour, Saied; Fernø, Johan; Nedrebø, Bjørn G; Cramariuc, Dana

Preoperative risk factors associated with left ventricular dysfunction after bariatric surgery Journal Article

In: Sci Rep, vol. 14, no. 1, pp. 2173, 2024, ISSN: 2045-2322.

Abstract | Links | BibTeX

40.

Kupjetz, Marie; Patt, Nadine; Joisten, Niklas; Ueland, Per Magne; McCann, Adrian; Gonzenbach, Roman; Bansi, Jens; Zimmer, Philipp

Baseline Inflammation but not Exercise Modality Impacts Exercise-induced Kynurenine Pathway Modulation in Persons With Multiple Sclerosis: Secondary Results From a Randomized Controlled Trial Journal Article

In: Int J Tryptophan Res, vol. 17, pp. 11786469241284423, 2024, ISSN: 1178-6469.

Abstract | Links | BibTeX

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